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Dietary intake of vitamin C and vitamin E and the development of hypertensive disorders of pregnancy

Rumbold, Alice R., Maats, Frederike H. E. and Crowther, Caroline A. (2005). Dietary intake of vitamin C and vitamin E and the development of hypertensive disorders of pregnancy. European Journal of Obstetrics Gynecology and Reproductive Biology,119(1):67-71.

Document type: Journal Article
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IRMA ID 0HON0185xPUB12
Title Dietary intake of vitamin C and vitamin E and the development of hypertensive disorders of pregnancy
Author Rumbold, Alice R.
Maats, Frederike H. E.
Crowther, Caroline A.
Journal Name European Journal of Obstetrics Gynecology and Reproductive Biology
Publication Date 2005
Volume Number 119
Issue Number 1
ISSN 0301-2115   (check CDU catalogue open catalogue search in new window)
Start Page 67
End Page 71
Total Pages 5
Publisher Elsevier
Field of Research 1114 - Paediatrics and Reproductive Medicine
HERDC Category C1 - Journal Article (DEST)
Abstract OBJECTIVES: To explore the relationship, if any, between dietary intake of the antioxidant vitamins C and E, and the development of pre-eclampsia and gestational hypertension. STUDY DESIGN: A prospective cohort study of pregnant women attending the antenatal clinic of the Women's and Children's Hospital in Adelaide, Australia, was carried out between April and July 2001. Women completed a semi-quantitative 116-item food frequency questionnaire (FFQ). Women's medical records were viewed after birth to collect data on pregnancy outcomes. Relationships were explored through cross-tabulations, chi-square analysis, and adjustments were made for potential confounders using binary logistic regression. RESULTS: A total of 299 women completed the FFQ. Median intake of vitamin C was 188 mg and for vitamin E was 6.74 mg. There was no relationship between the intake of vitamin C and hypertensive disorders of pregnancy. For vitamin E, being in the lowest quartile of intake, was associated with an increased risk of hypertensive disorders (RR 1.75, 95% CI 1.11-2.75, P = 0.02). This relationship was confirmed after adjusting for the confounding factors of maternal age and parity. CONCLUSIONS: Little support was found for a relationship between dietary intake of vitamin C and the development of hypertensive disorders of pregnancy. Low vitamin E intake was associated with a significant increase in the risk of hypertensive disorders of pregnancy, even after adjustments were made for confounding factors. Further research is required to investigate whether supplementation above dietary intake of antioxidant vitamins influences the risk of hypertensive disorders of pregnancy
Keywords Australia
Birth
Children
Hypertension
Hypertension,Pregnancy-Induced
Medical
Pre-Eclampsia
Pregnancy
DOI http://dx.doi.org/10.1016/j.ejogrb.2004.06.027   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST