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αEβ7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population

Woodberry, Tonia, Suscovich, Todd J., Henry, Leah M., August, Meredith, Waring, Michael T., Kaur, Amitinder, Hess, Christoph, Kutok, Jeffrey L., Aster, Jon C., Wang, Frederick, Scadden, David T. and Brander, Christian (2005). αEβ7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. Journal of Immunology,175(7):4355-4362.

Document type: Journal Article
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Title αEβ7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population
Author Woodberry, Tonia
Suscovich, Todd J.
Henry, Leah M.
August, Meredith
Waring, Michael T.
Kaur, Amitinder
Hess, Christoph
Kutok, Jeffrey L.
Aster, Jon C.
Wang, Frederick
Scadden, David T.
Brander, Christian
Journal Name Journal of Immunology
Publication Date 2005
Volume Number 175
Issue Number 7
ISSN 0022-1767   (check CDU catalogue open catalogue search in new window)
Start Page 4355
End Page 4362
Total Pages 8
Place of Publication US
Publisher American Association of Immunologists
Field of Research 1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract The characterization of antiviral CTL responses has largely been limited to assessing Ag-specific immune responses in the peripheral blood. Consequently, there is an incomplete understanding of the cellular immune responses at mucosal sites where many viruses enter and initially replicate and how the Ag specificity and activation status of CTL derived from these mucosal sites may differ from that of blood-derived CTL. In this study, we show that EBV-specific CTL responses in the tonsils are of comparable specificity and breadth but of a significantly higher magnitude compared with responses in the peripheral blood. EBV-specific, tonsil-resident, but not PBMC-derived, T cells expressed the integrin/activation marker CB103 (αEβ7), consistent with the detection of its ligand, E-cadherin, on tonsillar squamous cells. These CD8-positive, CD103-positive, tonsil-derived CTL were largely CCR7- and CD45RA- negative effector-memory cells and responded to lower Ag concentrations in in vitro assays than their CD103-negative PBMC-derived counterparts. Thus, EBV-specific CTL in the tonsil, a crucial site for EBV entry and replication, are of greater magnitude and phenotypically distinct from CTL in the peripheral blood and may be important for effective control of this orally transmitted virus.
Keywords Antigens,Viral
biosynthesis
blood
Cadherins
Comparative Study
cytology
Epitopes,T-Lymphocyte
Epstein-Barr Virus Infections
genetics
Herpesvirus 4,Human
Immunohistochemistry
Immunologic Memory
immunology
Integrins
Ligands
metabolism
physiology
Population
T-Lymphocytes,Cytotoxic
Tonsil
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST