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Plasma Interleukin-12 in malaria-tolerant Papua New Guineans: inverse correlation with Plasmodium falciparum Parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity

Boutlis, Craig S., Lagog, Moses, Chaisavaneeyakorn, Sujittra, Misukonis, Mary A., Bockarie, Moses J., Mgone, Charles S., Wang, Zhiqiang, Morahan, Grant, Weinberg, J. Brice, Udhayakumar, Venkatachalam and Anstey, Nicholas M. (2003). Plasma Interleukin-12 in malaria-tolerant Papua New Guineans: inverse correlation with Plasmodium falciparum Parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. Infection and Immunity,71(11):6354-6357.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 9 times in Scopus Article | Citations

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Title Plasma Interleukin-12 in malaria-tolerant Papua New Guineans: inverse correlation with Plasmodium falciparum Parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity
Author Boutlis, Craig S.
Lagog, Moses
Chaisavaneeyakorn, Sujittra
Misukonis, Mary A.
Bockarie, Moses J.
Mgone, Charles S.
Wang, Zhiqiang
Morahan, Grant
Weinberg, J. Brice
Udhayakumar, Venkatachalam
Anstey, Nicholas M.
Journal Name Infection and Immunity
Publication Date 2003
Volume Number 71
Issue Number 11
ISSN 0019-9567   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-0242381220
Start Page 6354
End Page 6357
Total Pages 4
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 1103 - Clinical Sciences
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. To better define the relationships between IL-12, NO, malaria parasitemia, and IL12B polymorphisms during malarial tolerance, plasma IL-12 levels and peripheral blood mononuclear cell NO synthase (NOS) activity were measured in asymptomatic Papua New Guineans exposed to intense malaria transmission. The IL-12 level was strongly inversely correlated with the density of Plasmodium falciparum parasitemia (ρ = −0.45; P < 0.001) and was predicted to decrease by 19% (95% confidence interval [CI], 10 to 27%) for each twofold increase in P. falciparum parasitemia. This is consistent with a suppressive effect of parasitemia on IL-12 production, an effect previously shown in vitro and in rodent models of disease. The IL-12 level was inversely correlated with NOS activity (r = −0.22; P = 0.007), with each twofold increase in NOS activity being predictive of a 25% (95% CI, 7 to 38%) decrease in plasma IL-12 levels. This probably reflects additional down-regulation of IL-12 by the high basal NO production and monocyte NOS expression found in the malaria-tolerant state. Neither the IL-12 level nor NOS activity was associated with either of two IL12B polymorphisms, reflecting the diversity of genetic control over immune responses in different populations.
Keywords malaria
Plasmodium falciparum
DOI http://dx.doi.org/10.1128/IAI.71.11.6354-6357.2003   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology


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