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Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling

Finn, James P., Ebert, T. R., Withers, R. T., Carey, M. F., Mackay, M., Phillips, J. W. and Febbraio, M. A. (2001). Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling. European Journal of Applied Physiology,84(3):238-243.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 25 times in Scopus Article | Citations

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Title Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling
Author Finn, James P.
Ebert, T. R.
Withers, R. T.
Carey, M. F.
Mackay, M.
Phillips, J. W.
Febbraio, M. A.
Journal Name European Journal of Applied Physiology
Publication Date 2001
Volume Number 84
Issue Number 3
ISSN 1439-6319   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-0035093329
Start Page 238
End Page 243
Total Pages 6
Place of Publication Berlin, Germany
Publisher Springer Publishing Company
HERDC Category C1 - Journal Article (DEST)
Abstract This double blind study investigated the effect of oral creatine supplementation (CrS) on 4 x 20 s of maximal sprinting on an air-braked cycle ergometer. Each sprint was separated by 20 s of recovery. A group of 16 triathletes [mean age 26.6 (SD 5.1) years. mean body mass 77.0 (SD 5.8) kg, mean body fat 12.9 (SD 4.6)%, maximal oxygen uptake 4.86 (SD 0.7) 1 min(-1)] performed an initial 4 x 20 s trial after a muscle biopsy sample had been taken at rest. The subjects were then matched on their total intramuscular creatine content (TCr) before being randomly assigned to groups to take by mouth either a creatine supplement (CRE) or a placebo (CON) before a second 4 x 20 s trial. PL muscle biopsy sample was also taken immediately before this second trial. The CrS of 100 g comprised 4 x 5 g for 5 days. The initial mean TCr were 112.5 (SD 8.7) and 112.5 (SD 10.7) mmol (.) kg(-1) dry mass for CRE and CON, respectively. After creatine loading and placebo ingestion respectively, CRE [128.7 (SD 11.8)mmol (.) kg(-1) dry mass] had a greater (P = 0.01) TCr than CON [112.0 (SD 10.0) mmol kg(-1) dry mass]. While the increase in free creatine for CRE was statistically significant (P = 0.034), this was not so for the changes in phosphocreatine content [trial 1: 75.7 (SD 6.9), trial 2.84.7 (SD 11.0) mmol (.) kg(-1) dry mass, P = 0.091]. There were no significant differences between CRE and CON for citrate synthase activity (P = 0.163). There was a tendency towards improved performance in terms of I s peak power tin watts P = 0.07; in watts per kilogram P = 0.05), 5 s peak power tin watts P = 0.08) and fatigue index (P = 0.08) after CrS for sprint 1 of the second trial. However, there was no improvement for mean power tin watts P = 0.15; in watts per kilogram P = 0.1) in sprint 1 or for any performance values in subsequent sprints. Our results suggest that, while CrS elevates the intramuscular stores of free creatine, this does not have an ergogenic effect on 4 x 20 s all-out cycle sprints with intervening 20-s rest periods.
Keywords creatine supplementation
peak power
muscle enzyme activity
human skeletal-muscle
phosphocreatine resynthesis
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