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Effects of a topical essential oil-containing formulation on biofilm-forming coagulase-negative staphylococci

Al-Shuneigat, J., Cox, Sean D. and Markham, J. L. (2005). Effects of a topical essential oil-containing formulation on biofilm-forming coagulase-negative staphylococci. Letters in Applied Microbiology,41(1):52-55.

Document type: Journal Article
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Title Effects of a topical essential oil-containing formulation on biofilm-forming coagulase-negative staphylococci
Author Al-Shuneigat, J.
Cox, Sean D.
Markham, J. L.
Journal Name Letters in Applied Microbiology
Publication Date 2005
Volume Number 41
Issue Number 1
ISSN 0266-8254   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-21344438434
Start Page 52
End Page 55
Total Pages 4
Place of Publication Oxford
Publisher Blackwell Science
HERDC Category C1 - Journal Article (DEST)
Abstract Aims: To evaluate the antimicrobial effects of Polytoxinol(TM) (PT), a topical essential oil-based formulation, against biofilm positive strains of coagulase-negative staphylococci. Methods and Results: Using a microtitre plate assay we measured inhibitory effects for PT against a selection of biofilm-forming clinical isolates of coagulase-negative staphylococci. Susceptibility varied considerably (MIC = 0.6-20 000 ppm). For the most tolerant clinical isolate (Staphylococcus warneri) biofilm growth was inhibited by a 32-fold lower PT concentration than planktonic growth. This inhibition of biofilm development, which was not observed with the other test isolates, was related to an inhibition of the initial phase of S. warneri cell adherence to the polystyrene surface. Conclusion: The antimicrobial efficacy of PT was verified against clinical isolates of coagulase-negative staphylococci in vitro. PT was able to inhibit biofilm formation in the most tolerant isolate at sub-inhibitory concentrations. Significance and Impact of the Study: These observations indicate that an ability to prevent biofilm formation, independently of effects on cell viability may contribute to the in vivo topical efficacy of essential oils.
Keywords biofilm
coagulase-negative staphylococci
essential oil formulation
polytoxinol (tm)
polysaccharide intercellular adhesin
epidermidis
hemagglutination
DOI http://dx.doi.org/10.1111/j.1472-765X.2005.01699.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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