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Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand

Cheng, Allen C., Peacock, Sharon J., Limmathurotsakul, Direk, Wongsuvan, Gumphol, Chierakul, Wirongrong, Amornchai, Premjit, Getchalarat, Nongluk, Chaowagul, Wipada, White, Nicholas J., Day, Nicholas P. J. and Wuthiekanun, Vanaporn (2006). Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene,100(1):64-67.

Document type: Journal Article
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Title Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand
Author Cheng, Allen C.
Peacock, Sharon J.
Limmathurotsakul, Direk
Wongsuvan, Gumphol
Chierakul, Wirongrong
Amornchai, Premjit
Getchalarat, Nongluk
Chaowagul, Wipada
White, Nicholas J.
Day, Nicholas P. J.
Wuthiekanun, Vanaporn
Journal Name Transactions of the Royal Society of Tropical Medicine and Hygiene
Publication Date 2006
Volume Number 100
Issue Number 1
ISSN 0035-9203   (check CDU catalogue open catalogue search in new window)
Start Page 64
End Page 67
Place of Publication Oxford
Publisher Elsevier
HERDC Category C1 - Journal Article (DEST)
Abstract A prospective study was performed to compare a rapid immunochromogenic cassette test (ICT) with the indirect haemagglutination assay (IHA) and clinical rules for the diagnosis of melioidosis in an endemic area. The sensitivity and specificity of the IgG ICT was 86% and 47%, and the IgM ICT was 82% and 47%, respectively. These were similar to the results for IHA (sensitivity 73%, specificity 64%) and clinical rules (73% and 37%). ICT lacks clinical utility as a result of high background rates of positive Burkholderia pseudomallei serology in this population. Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Keywords melioidosis
burkholderia pseudomallei
immunochromogenic cassette test
indirect haemagglutination assay
thailand
immunoglobulin-m
endemicity
area
DOI http://dx.doi.org/10.1016/j.trstmh.2005.04.019   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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