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Phosphodiesterase 4 inhibition with roflumilast: a new approach to pulmonary disease

Doggrell, SA (2006). Phosphodiesterase 4 inhibition with roflumilast: a new approach to pulmonary disease. Expert Opinion on Pharmacotherapy,7(4):485-488.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 2 times in Scopus Article | Citations

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Title Phosphodiesterase 4 inhibition with roflumilast: a new approach to pulmonary disease
Author Doggrell, SA
Journal Name Expert Opinion on Pharmacotherapy
Publication Date 2006
Volume Number 7
Issue Number 4
ISSN 1465-6566   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33644916111
Start Page 485
End Page 488
Total Pages 4
Publisher Informa Healthcare
HERDC Category C1 - Journal Article (DEST)
Abstract Asthma is a very common condition that can be managed well pharmacologically. In contrast, the presently available management of chronic obstructive pulmonary disease (COPD) is poor. The phosphodiesterase 4 inhibitor roflumilast has an anti-inflammatory effect, and has recently been shown to reduce the early and late responses in mild allergic asthma. Roflumilast may become a steroid-free option for those patients who do not tolerate or want to take long-term corticosteroids to prevent asthma. In COPD, roflumilast improved measures of pulmonary function, quality of life and well being. As the inflammation of COPD is resistant to corticosteroids, roflumilast has potential as an anti-inflammatory agent in the treatment of COPD. Roflumilast is generally well tolerated.
Keywords asthma
chronic obstructive pulmonary disease
pde4 inhibition
roflumilast
inhaled corticosteroids
asthma
DOI http://dx.doi.org/10.1517/14656566.7.4.485   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 28 Nov 2007, 14:16:08 CST