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Is NXY-059 an advancement in the treatment of acute ischaemic stroke?

Doggrell, SA (2006). Is NXY-059 an advancement in the treatment of acute ischaemic stroke?. Expert Opinion on Pharmacotherapy,7(7):965-968.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article

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Title Is NXY-059 an advancement in the treatment of acute ischaemic stroke?
Author Doggrell, SA
Journal Name Expert Opinion on Pharmacotherapy
Publication Date 2006
Volume Number 7
Issue Number 7
ISSN 1465-6566   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33646561523
Start Page 965
End Page 968
Total Pages 4
Publisher Informa Healthcare
HERDC Category C1 - Journal Article (DEST)
Abstract The only pharmacological treatment for acute ischaemic stroke used at present is tissue plasminogen activator. The nitrone NXY-049 has been shown to be neuroprotective in a variety of animal models. The SAINT (Stoke Acute Ischemic NXY-059 Treatment) 1 trial has shown that, on the modified Rankin scale at 90 days, there were slightly more patients with no symptoms in the NXY-059 group than the placebo group. Conversely, there were slightly fewer patients with a score of 4 (moderately-severe disability) in the NXY-059 group than placebo group. NXY-059 was well tolerated. These data suggest that NXY-059 may be a modest advancement for the treatment of acute ischaemic stroke.
Keywords acute ischaemic stroke
nitrones
nxy-059
focal cerebral-ischemia
stilbazulenyl nitrone
antioxidant
transient
occlusion
agent
model
rat
DOI http://dx.doi.org/10.1517/14656566.7.7.965   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 28 Nov 2007, 14:16:08 CST