Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Muraglitazar: beneficial or detrimental in the treatment of Type 2 diabetes?

Doggrell, SA (2006). Muraglitazar: beneficial or detrimental in the treatment of Type 2 diabetes?. Expert Opinion on Pharmacotherapy,7(9):1229-1233.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 4 times in Scopus Article | Citations

Google Scholar Search Google Scholar

Title Muraglitazar: beneficial or detrimental in the treatment of Type 2 diabetes?
Author Doggrell, SA
Journal Name Expert Opinion on Pharmacotherapy
Publication Date 2006
Volume Number 7
Issue Number 9
ISSN 1465-6566   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33745434061
Start Page 1229
End Page 1233
Total Pages 5
Publisher Informa Healthcare
HERDC Category C1 - Journal Article (DEST)
Abstract Hyperglycaemia in Type 2 diabetes has a major role in the development of microvascular complications, whereas the dyslipidaemia is the major cause of macrovascular complications. In patients with Type 2 diabetes, activation of PPAR-alpha and PPAR-gamma with the fibrates and glitazones improves dyslipidaemia and increases insulin sensitivity, respectively. Muraglitazar is an agonist at both of these receptors and has been shown to increase high-density lipoprotein cholesterol, decrease triglycerides and improve insulin sensitivity. However, there is also some evidence that muraglitazar has detrimental effects on the cardiovascular system. Before muraglitazar is widely used in the treatment of Type 2 diabetes, more safety testing needs to be undertaken.
Keywords high-density lipoprotein cholesterol
hyperglycaemia
insulin sensitivity
muraglitazar
ppar-alpha
ppar-gamma
triglycerides
type 2 diabetes
trial
intervention
activator
mellitus
insulin
disease
events
DOI http://dx.doi.org/10.1517/14656566.7.9.1229   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 75 Abstract Views  -  Detailed Statistics
Created: Wed, 28 Nov 2007, 14:16:08 CST