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After the failure of citalopram for depression, what next?

Doggrell, SA (2006). After the failure of citalopram for depression, what next?. Expert Opinion on Pharmacotherapy,7(11):1515-1518.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 1 times in Scopus Article | Citations

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Title After the failure of citalopram for depression, what next?
Author Doggrell, SA
Journal Name Expert Opinion on Pharmacotherapy
Publication Date 2006
Volume Number 7
Issue Number 11
ISSN 1465-6566   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33746850501
Start Page 1515
End Page 1518
Total Pages 4
Publisher Informa Healthcare
HERDC Category C1 - Journal Article (DEST)
Abstract The choice of treatment after failure of selective serotonin re-uptake inhibitors in the treatment of depression largely depends on the preferences of the physician. The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) trials set out to rationalise the treatment of depression after the failure of citalopram. When subjects who were unresponsive or intolerant to citalopram were switched to sustained-release bupropion, sertaline or extended-release venlafaxine, remission rates were similar (21, 18 and 25%, respectively). When subjects who were unresponsive to citalopram had sustained-release bupropion or buspirone added to citalopram, there were similar remission rates of 29.7 and 30.1%, respectively. The interpretation of this data are complicated by the lack of placebo groups. One interpretation is that sustained-release bupropion, sertaline or extended-release venlafaxine are equally effective in subjects with major depression after the failure of citalopram, and that sustained-release bupropion or buspirone are equally effective when added to citalopram in subjects with major depression after the failure of citalopram. An alternative explanation is that none of the drugs are effective in citalopram failure, and the responses are the placebo effect.
Keywords bupropion
buspirone
citalopram
extended-release venlafaxine
sustained-release bupropion
major depression
selective serotonin re-uptake inhibitor
sertaline
ssri
venlafaxine
major depression
double-blind
placebo
augmentation
sertraline
buspirone
efficacy
safety
ssris
xr
DOI http://dx.doi.org/10.1517/14656566.7.11.1515   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 28 Nov 2007, 14:16:08 CST