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Liver fluke vaccines: Vaccination Against Fasciolosis by a Multivalent Vaccine of Recombinant Stage-Specific Antigens

Jayaraj, Ramamoorthi, Piedrafita, D., Dynon, K., Grams, R., Spithill, T. W. and Smooker, P. M. (2010). Liver fluke vaccines: Vaccination Against Fasciolosis by a Multivalent Vaccine of Recombinant Stage-Specific Antigens. In: 3rd Vaccine Global Congress, Singapore, 4-6 October 2009.

Document type: Conference Paper
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IRMA ID 83093774xPUB203
Author Jayaraj, Ramamoorthi
Piedrafita, D.
Dynon, K.
Grams, R.
Spithill, T. W.
Smooker, P. M.
Title Liver fluke vaccines: Vaccination Against Fasciolosis by a Multivalent Vaccine of Recombinant Stage-Specific Antigens
Conference Name 3rd Vaccine Global Congress
Conference Location Singapore
Conference Dates 4-6 October 2009
Conference Publication Title Procedia in Vaccinology
Place of Publication Netherlands
Publisher Elsevier BV
Publication Year 2010
Volume Number 2
Issue Number 1
ISSN 1877-282X   (check CDU catalogue  open catalogue search in new window)
Start Page 82
End Page 85
Total Pages 4
HERDC Category E1 - Conference Publication (DIISR)
Abstract Fasciola's excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These cysteine proteases are proposed as major mediators of parasitism, and are considered targets for vaccination. In order to assess the vaccine efficacy of these enzymes, single and multivalent recombinant protein vaccinations of adult-stage F. hepatica cathepsin L5, metacercarial-stage F. gigantica cathepsin L1 g and juvenile-stage F. hepatica cathepsin B were analysed in rats against F. hepatica challenge infection. The protective efficacy of anti-fluke vaccines was evaluated in terms of parasitological parameters (recovered fluke burden, fluke body size and wet weight) and pathological changes (liver damage score) in rats. The rats vaccinated with recombinant proteins were shown to have significantly fewer and smaller flukes than the control rats. A maximum protection of 83% was seen in the group vaccinated with a combination of cathepsin B and cathepsin L5.
Keyword Cathepsin proteases
Multivalent vaccines
Fasciola
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to published version
Link to CC Attribution 3.0 License
URL http://www.sciencedirect.com/science/article/pii/S1877282X10000160
https://creativecommons.org/licenses/by/3.0/au


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