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Incomplete protection against hepatitis B among remote Aboriginal adolescents despite full vacination in infancy

Dent, Elizabeth, Selvey, Christine E., Bell, Andrew, Davis, Joshua S. and McDonald, Malcolm I. (2010). Incomplete protection against hepatitis B among remote Aboriginal adolescents despite full vacination in infancy. Communicable Diseases Intelligence,34(4):435-439.

Document type: Journal Article
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IRMA ID 81704288xPUB206
Title Incomplete protection against hepatitis B among remote Aboriginal adolescents despite full vacination in infancy
Author Dent, Elizabeth
Selvey, Christine E.
Bell, Andrew
Davis, Joshua S.
McDonald, Malcolm I.
Journal Name Communicable Diseases Intelligence
Publication Date 2010
Volume Number 34
Issue Number 4
ISSN 0725-3141   (check CDU catalogue open catalogue search in new window)
Start Page 435
End Page 439
Total Pages 5
Place of Publication Canberra, ACT, Australia
Publisher Australian Government. Department of Health and Ageing. Office of Health Protection, Surveillance Branch
HERDC Category C1 - Journal Article (DIISR)
Abstract The objective of this study was to determine long-term immunity to hepatitis B virus (HBV) in a cohort of adolescents who received plasma-derived HBV vaccine in 1989 and 1990 in a remote Australian Aboriginal community. This was done using a serological survey; primary outcome measures were cut-off titres of HBsAb, and the presence of HBcAb and/or HBsAg. Of 37 adolescents in the cohort, 4 (11%) had evidence of active infection, one with abnormal liver enzymes, 7 (19%) had evidence of past infection, 15 (41%) were HBsAb positive in low titre and 11 (30%) were classed as immune. It was concluded that there was relatively poor long-term serological immunity to HBV vaccination in this group; a finding which is in keeping with similar studies in Indigenous and remote populations elsewhere. This finding raises the concern that a significant proportion of Aboriginal adolescents in other remote communities (vaccinated in 1989 and 1990) were not adequately protected by the vaccine. If so, there will be an unexpected burden of chronic HBV infection in these settings and a substantial group who are non-immune, despite having received complete HBV vaccination courses as infants. The authors recommend follow-up serosurveys in remote Aboriginal communities to identify people with low HBsAb titres, especially those without an adequate anamnestic response to another dose of HBV vaccine. In addition, community-based active surveillance programs will be required to detect people with chronic HBV infection and provide access to monitoring and appropriate treatment. Commun Dis Intell 2010;34(4):435–439.

Keywords Indigenous
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