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Methodology and measurement of the effectivesnesss of Haemophilus influenzae thyp b vaccine: Systematic Review

O'Loughlin, Rosalyn E., Edmond, Karen, Mangtani, Punam, Cohen, Adam L., Shetty, Sharmila, Hajjeh, Rana and Mulholland, E. Kim (2010). Methodology and measurement of the effectivesnesss of Haemophilus influenzae thyp b vaccine: Systematic Review. Vaccine,28(38):6128-6236.

Document type: Journal Article

IRMA ID 81704288xPUB254
Title Methodology and measurement of the effectivesnesss of Haemophilus influenzae thyp b vaccine: Systematic Review
Author O'Loughlin, Rosalyn E.
Edmond, Karen
Mangtani, Punam
Cohen, Adam L.
Shetty, Sharmila
Hajjeh, Rana
Mulholland, E. Kim
Journal Name Vaccine
Publication Date 2010
Volume Number 28
Issue Number 38
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 6128
End Page 6236
Total Pages 108
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract The use of the highly effective Haemophilus influenzae type b (Hib) conjugate vaccine has increased globally. We review the benefits and limitations of studies measuring Hib vaccine effectiveness (VE). We critically examine the case-control approach by assessing the similarities and differences in methodology and findings and discuss the need for future Hib VE studies. In the absence of good surveillance data, vaccine effectiveness studies can play an important role, particularly with the increasing use of pneumococcal vaccine that has not been well tested under field conditions in less developed countries. However, the effectiveness of Hib vaccine has been well documented so the need for future VE Hib studies is minimal.
Keywords Vaccine effectiveness
Case–control studies
Haemophilus influenza type b vaccine
DOI http://dx.doi.org/10.1016/j.vaccine.2010.06.107   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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