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Whole-genome characterization and genotyping of global WU polymavirus strains

Bialasiewicz, Seweryn, Rockett, Rebecca, Whiley, David W., Abed, Yacine, Allander, Tobias, Binks, Michael J., Boivin, Guy, Cheng, Allen C., Chung, Ju-Young, Ferguson, Patricia E., Gilroy, Nicole M., Leach, Amanda J., Lindau, Cecilia, Rossen, John W., Sorrell, Tania C., Nissen, Michael D. and Sloots, Theo P. (2010). Whole-genome characterization and genotyping of global WU polymavirus strains. Journal of Virology,84(12):6229-6234.

Document type: Journal Article
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IRMA ID 81704288xPUB263
Title Whole-genome characterization and genotyping of global WU polymavirus strains
Author Bialasiewicz, Seweryn
Rockett, Rebecca
Whiley, David W.
Abed, Yacine
Allander, Tobias
Binks, Michael J.
Boivin, Guy
Cheng, Allen C.
Chung, Ju-Young
Ferguson, Patricia E.
Gilroy, Nicole M.
Leach, Amanda J.
Lindau, Cecilia
Rossen, John W.
Sorrell, Tania C.
Nissen, Michael D.
Sloots, Theo P.
Journal Name Journal of Virology
Publication Date 2010
Volume Number 84
Issue Number 12
ISSN 0022-538X   (check CDU catalogue open catalogue search in new window)
Start Page 6229
End Page 6234
Total Pages 6
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract Exploration of the genetic diversity of WU polyomavirus (WUV) has been limited in terms of the specimen numbers and particularly the sizes of the genomic fragments analyzed. Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). The discriminatory power of the previous VP2 fragment typing method was found to be limited, and a new, larger genotyping region within the VP2/1 interface was proposed.

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