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Antibodies to serotype 9V exhibit novel serotype cross-reactivity following infant pneumococcal

Licciardi, Paul V., Balloch, Anne, Russell, Fiona, Mulholland, E. Kim and Tang, Mimi (2010). Antibodies to serotype 9V exhibit novel serotype cross-reactivity following infant pneumococcal. Vaccine,28(22):3793-3800.

Document type: Journal Article

IRMA ID 81704288xPUB304
Title Antibodies to serotype 9V exhibit novel serotype cross-reactivity following infant pneumococcal
Author Licciardi, Paul V.
Balloch, Anne
Russell, Fiona
Mulholland, E. Kim
Tang, Mimi
Journal Name Vaccine
Publication Date 2010
Volume Number 28
Issue Number 22
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 3793
End Page 3800
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract Cross-reactivity within the pneumococcal immune response was examined in this study. Significant cross-reactivity between serotypes 9V, 15B and 19A was identified in infant post-immunization serum that could not be effectively titrated during specific IgG measurements. Pre-absorption using serotype 9V inhibited this cross-reactivity and normalized titratability in the WHO ELISA for serotypes 15B and 19A. However, this did not affect functional avid IgG and was associated with fewer pneumococcal conjugate vaccine (PCV) doses, suggesting that cross-reactive antibodies were of low avidity. The results in this study have important implications for assessment of vaccine immunogenicity.
Keywords Pneumococcal
Cross-reactive
Antibody
DOI http://dx.doi.org/10.1016/j.vaccine.2010.03.033   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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