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Cross-neutralisation of Australian brown snake taipan and death adder venoms by monovalent antibodies

Isbister, Geoffrey K., O'Leary, Margaret A., Hagan, Jessica, Nichols, Kearney, Jacoby, Tamara, Davern, Kathleen, Hodgson, Wayne C. and Schneider, Jennifer J. (2010). Cross-neutralisation of Australian brown snake taipan and death adder venoms by monovalent antibodies. Vaccine,28:798-802.

Document type: Journal Article
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IRMA ID 81704288xPUB46
Title Cross-neutralisation of Australian brown snake taipan and death adder venoms by monovalent antibodies
Author Isbister, Geoffrey K.
O'Leary, Margaret A.
Hagan, Jessica
Nichols, Kearney
Jacoby, Tamara
Davern, Kathleen
Hodgson, Wayne C.
Schneider, Jennifer J.
Journal Name Vaccine
Publication Date 2010
Volume Number 28
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 798
End Page 802
Total Pages 4
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract An understanding of the cross-neutralisation of snake venoms by antibodies is important for snake antivenom development. We investigated the cross-neutralisation of brown snake (Pseudonaja textilis) venom, taipan (Oxyuranus scutellatus) venom and death adder (Acanthophis antarcticus) with commercial antivenoms and monovalent anti-snake IgG, using enzyme immunoassays, in vitro clotting and neurotoxicity assays. Each commercial antivenom bound all three venoms, and neutralised clotting activity of brown snake and taipan venoms and neurotoxicity of death adder venom. The 'in-house' monovalent anti-snake venom IgG raised against procoagulant brown snake and taipan venoms, did not neutralise the neurotoxic effects of death adder venom. However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms.
Keywords Antivenom
Cross-neutralisation
Snake venom
DOI http://dx.doi.org/10.1016/j.vaccine.2009.10.055   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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