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Sibutramine for obesity in adolescents

Doggrell, SA (2006). Sibutramine for obesity in adolescents. Expert Opinion on Pharmacotherapy,7(17):2435-2438.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 2 times in Scopus Article | Citations

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Title Sibutramine for obesity in adolescents
Author Doggrell, SA
Journal Name Expert Opinion on Pharmacotherapy
Publication Date 2006
Volume Number 7
Issue Number 17
ISSN 1465-6566   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33751576810
Start Page 2435
End Page 2438
Total Pages 4
Publisher Informa Healthcare
HERDC Category C1 - Journal Article (DEST)
Abstract In adolescents, there is an epidemic of being overweight or obese. Sibutramine has been shown to cause sustained loss of weight in adults. in a study based in Mexico City, adolescents with a BMI of 35/36 kg/m(2), who were put on a hypocaloric diet and undertook physical activity, lost 4.3 kg in 6 months, and this loss was increased to 7.3 kg by sibutramine. Similarly, in a study based in the US, there was a loss of 1.9 kg in the placebo group of obese adolescents with a hypocaloric diet and increased physical activity at the end of 12 months, and this was increased to 6.5 kg in the sibutramine group. Sibutramine has a slight tendency to increase blood pressure and heart rate, and seems to be more effective than orlistat in causing weight loss in adolescents. However, orlistat does not have negative effects on blood pressure. Long-term follow-up studies of sibutramine in adolescents are needed to determine whether the weight loss is maintained, and whether the weight loss translates into better clinical outcomes.
Keywords adolescent obesity
randomized controlled-trial
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Created: Wed, 28 Nov 2007, 14:16:08 CST