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Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months age, following one, two or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

Russell, Fiona, Licciardi, Paul V., Balloch, Anne, Biaukula, Viema, Tikoduadua, Lisi, Carapetis, Jonathan R., Nelson, Jane N., Jenney, Adam, Waqatakirewa, Lepani, Colquhoun, Samantha, Cheung, Yin, Tang, Mimi and Mulholland, E. Kim (2010). Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months age, following one, two or three doses of the 7-valent pneumococcal conjugate vaccine in infancy. Vaccine,28(18):3086-3094.

Document type: Journal Article

IRMA ID 81704288xPUB51
Title Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months age, following one, two or three doses of the 7-valent pneumococcal conjugate vaccine in infancy
Author Russell, Fiona
Licciardi, Paul V.
Balloch, Anne
Biaukula, Viema
Tikoduadua, Lisi
Carapetis, Jonathan R.
Nelson, Jane N.
Jenney, Adam
Waqatakirewa, Lepani
Colquhoun, Samantha
Cheung, Yin
Tang, Mimi
Mulholland, E. Kim
Journal Name Vaccine
Publication Date 2010
Volume Number 28
Issue Number 18
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 3086
End Page 3094
Total Pages 8
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p<0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group.
Keywords Pneumococcal
Polysaccharide
Booster
DOI http://dx.doi.org/10.1016/j.vaccine.2010.02.065   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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