Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

The epidemiology of community acquired bacteremic pneumonia due to Streptococcus pneumoniae in the Top End of the Northern Territory Australia-Over 22 years.

Jacups, Susan P. and Cheng, Allen C. (2011). The epidemiology of community acquired bacteremic pneumonia due to Streptococcus pneumoniae in the Top End of the Northern Territory Australia-Over 22 years.. Vaccine,29(33):5386-5392.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 7 times in Scopus Article | Citations
Altmetric Score Altmetric Score is 3
Google Scholar Search Google Scholar

IRMA ID 82057923xPUB30
Title The epidemiology of community acquired bacteremic pneumonia due to Streptococcus pneumoniae in the Top End of the Northern Territory Australia-Over 22 years.
Author Jacups, Susan P.
Cheng, Allen C.
Journal Name Vaccine
Publication Date 2011
Volume Number 29
Issue Number 33
ISSN 0264-410X   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-79960381830
Start Page 5386
End Page 5392
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract BACKGROUND:
Diseases caused by Streptococcus pneumoniae continue to cause substantial morbidity and mortality throughout the world. Furthermore, detrimental outcomes are more pronounced in some populations--such as those living in third world poverty, and Indigenous people who live in developed nations.

METHODS
:
This study describes the epidemiology of blood culture positive S. pneumoniae community-acquired pneumonia (CAP) in the Top End of the Northern Territory of Australia. Demographics, indigenous status, medical risk factors, serotype and outcomes were collected from adults presenting to hospital with blood culture positive S. pneumoniae CAP, from 1987 to 2008.

RESULTS:
We report 205 cases, with a median age of 40 years. The average overall incidence rate ratio was 10.3 for indigenous adults compared with non-indigenous adults. There was no statistical difference between incidence rates pre and post-23-valent pneumococcal polysaccharide vaccine (23vPPV) introduction. Serotypes in presenting cases were predominantly (84.7%) 23vPPV types. The whole-population logistic regression model identified significant adjusted relative risks: 95% CI, for age 45 and older 1.6: 1.1, 2.2, indigenous 5.9: 3.7, 9.5, diabetes 2.3: 1.6, 3.3, excess alcohol 4.8: 2.8, 8.3, smoking 2.7: 1.9, 3.7 with indigenous+excess alcohol 18.5: 17.3, 19.7 as predictive for bacteremic S. pneumoniae CAP presentation.

CONCLUSIONS:

Our results suggest that, the national 23vPPV program appears to be under-utilized. An integrated Public Health approach vigorously targeting indigenous adolescents, before substances such as alcohol and smoking are habitual, together with increased vaccine coverage, will reduce the burden of pneumococcal disease in this population.
Keywords Epidemiology
Australia
Indigenous
Pneumococcal vaccines
Risk factors
Pneumonia
Prospective studies
Tropical medicine
Poverty
Socioeconomic
DOI http://dx.doi.org/10.1016/j.vaccine.2011.05.082   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 20 Abstract Views  -  Detailed Statistics
Created: Fri, 17 Jan 2014, 00:49:03 CST