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Short courses of antibiotics for children and adults with bronchiectasis (Review)

Wurzel, Danielle, Marchant, Julie M., Yerkovich, Stephanie T., Upham, John W., Masters, Ian B. and Chang, Anne B. (2011). Short courses of antibiotics for children and adults with bronchiectasis (Review). Cochrane Database of Systematic Reviews,2011(6):1-18.

Document type: Journal Article
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IRMA ID jsingletonxPUB28
Title Short courses of antibiotics for children and adults with bronchiectasis (Review)
Author Wurzel, Danielle
Marchant, Julie M.
Yerkovich, Stephanie T.
Upham, John W.
Masters, Ian B.
Chang, Anne B.
Journal Name Cochrane Database of Systematic Reviews
Publication Date 2011
Volume Number 2011
Issue Number 6
ISSN 1469-493X   (check CDU catalogue open catalogue search in new window)
Start Page 1
End Page 18
Total Pages 18
Place of Publication United Kingdom
Publisher John Wiley & Sons Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Bronchiectasis is an important cause of respiratory morbidity in both developing and developed countries. Antibiotics are considered standard therapy in the treatment of this condition but it is unknown whether short courses (four weeks or less) are efficacious.

To determine whether short courses of antibiotics (i.e. less than or equal to four weeks) for treatment of acute and stable state bronchiectasis, in adults and children, are efficacious when compared to placebo or usual care.

Search methods
The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE, EMBASE, OLDMEDLINE, CINAHL, AMED and PsycINFO and handsearching of respiratory journals and meeting abstracts were performed by the Cochrane Airways Group up to February 2011.

Selection criteria
Only randomised controlled trials were considered. Adults and children with bronchiectasis (defined clinically or radiologically) were included. Patients with cystic fibrosis were excluded.

Data collection and analysis
Two review authors independently reviewed the titles, abstracts and citations to assess eligibility for inclusion. Only one study fulfilled the inclusion criteria and thus meta-analysis could not be performed.

Main results
The single eligible study showed a small benefit, when compared to placebo, of four weeks of inhaled antibiotic therapy in adults with bronchiectasis and pseudomonas in their sputum. There were no studies in children and no studies on oral or intravenous antibiotics.

Authors' conclusions
There is insufficient evidence in the current literature to make reasonable conclusions about the efficacy of short course antibiotics in the management of adults and children with bronchiectasis. Until further evidence is available, adherence to current treatment guidelines is recommended.
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