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Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age

Russell, Fiona M., Carapetis, Jonathan R., Burton, R. L., Lin, J., Licciardi, Paul V., Balloch, Anne, Tikoduadua, Lisi, Waqatakirewa, Lepani, Cheung, Yin, Tang, Mimi, Nahm, Moon H and Mulholland, E. Kim (2011). Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age. Vaccine,29:535-544.

Document type: Journal Article

IRMA ID jsingletonxPUB5
Title Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age
Author Russell, Fiona M.
Carapetis, Jonathan R.
Burton, R. L.
Lin, J.
Licciardi, Paul V.
Balloch, Anne
Tikoduadua, Lisi
Waqatakirewa, Lepani
Cheung, Yin
Tang, Mimi
Nahm, Moon H
Mulholland, E. Kim
Journal Name Vaccine
Publication Date 2011
Volume Number 29
ISSN 0264-410X   (check CDU catalogue  open catalogue search in new window)
Start Page 535
End Page 544
Total Pages 9
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) with or without 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months, and subsequent re-exposure to a small dose of pneumococcal polysaccharide antigens (mPPS) at 17 months. Fijian infants were randomized to receive 0, 1, 2, or 3 PCV-7 doses. Half received PPV-23 at 12 months and all received mPPS at 17 months. OPA was performed on up to 14 serotypes. Three and 2 PCV-7 doses resulted in similar OPA for most PCV-7 serotypes up to 9 months and for half of the serotypes at 12 months. A single dose improved OPA compared with the unvaccinated group. PPV-23 significantly improved OPA for all serotypes tested but in general, was associated with diminished responses following re-challenge.
Keywords Pneumococcal vaccination
Opsonophagocytic activity
DOI http://dx.doi.org/10.1016/j.vaccine.2010.10.046   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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