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Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates

McAllister, Lauren, Ogunniyi, Abiodun, Stroeher, Uwe, Leach, Amanda J. and Paton, James C. (2011). Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infection and Immunity,79(12):4839-4849.

Document type: Journal Article
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Title Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates
Author McAllister, Lauren
Ogunniyi, Abiodun
Stroeher, Uwe
Leach, Amanda J.
Paton, James C.
Journal Name Infection and Immunity
Publication Date 2011
Volume Number 79
Issue Number 12
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Start Page 4839
End Page 4849
Total Pages 11
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract The capsular serotype has long been associated with the virulence of Streptococcus pneumoniae. Here we present an in-depth study of phenotypic and genetic differences between serotype 3 and serogroup 11 S. pneumoniae clinical isolates from both the general and indigenous populations of Australia. Both serotypes/groups included clonally unrelated strains with differences in well-known polymorphic virulence genes, such as nanA and pspA, as demonstrated by multilocus sequence typing and Western blot analysis. Nonetheless, the serotype 3 strains were consistently and significantly more virulent in mice than the serogroup 11 strains. Despite extensive genomic analysis, noncapsular genes common to one serotype/group but not the other were not identified. Nevertheless, following the conversion of a serotype 11A isolate to serotype 3 and subsequent analysis in an intranasal infection model, it was evident that both capsular and noncapsular factors determine the virulence phenotype in mice. However, it appears that these noncapsular factors vary from strain to strain.

DOI http://dx.doi.org/10.1128/IAI.05663-11   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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