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Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: Evaluation from the CANVAS studies

Tong, Amy, Tong, Steven Y. C., Zhang, Yurong, Lamlertthon, Supaporn, Sharma-Kuinkel, Batu, Rude, Thomas, Ahn, Sun, Ruffin, Felicia, Llorens, Lily, Tamarana, Ganesh, Biek, Donald, Critchley, Ian and Fowler, Jr Vance (2012). Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: Evaluation from the CANVAS studies. PLoS One,7(5):e37212.

Document type: Journal Article
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IRMA ID bsmithxPUB129
NHMRC Grant No. 508829
Title Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: Evaluation from the CANVAS studies
Author Tong, Amy
Tong, Steven Y. C.
Zhang, Yurong
Lamlertthon, Supaporn
Sharma-Kuinkel, Batu
Rude, Thomas
Ahn, Sun
Ruffin, Felicia
Llorens, Lily
Tamarana, Ganesh
Biek, Donald
Critchley, Ian
Fowler, Jr Vance
Journal Name PLoS One
Publication Date 2012
Volume Number 7
Issue Number 5
ISSN 1932-6203   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84862106047
Start Page e37212
Total Pages 7
Place of Publication United States
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract The impact of Panton-Valentine leukocidin (PVL) on the severity of complicated skin and skin structure infections (cSSSI) caused by Staphylococcus aureus is controversial. We evaluated potential associations between clinical outcome and PVL presence in both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates from patients enrolled in two large, multinational phase three clinical trials assessing ceftaroline fosamil for the treatment of cSSSI (the CANVAS 1 and 2 programs). Isolates from all microbiologically evaluable patients with monomicrobial MRSA or MSSA infections (n = 473) were genotyped by PCR for pvl and underwent pulsed-field gel electrophoresis (PFGE). Genes encoding pvl were present in 266/473 (56.2%) isolates. Infections caused by pvl-positive S. aureus were associated with younger patient age, North American acquisition, and presence of major abscesses (P<0.001 for each). Cure rates of patients infected with pvl-positive and pvl-negative S. aureus were similar overall (93.6% versus 92.8%; P = 0.72), and within MRSA-infected (94.5% vs. 93.1%; P = 0.67) and MSSA-infected patients (92.2% vs. 92.7%; P = 1.00). This finding persisted after adjustment for multiple patient characteristics. Outcomes were also similar when USA300 PVL+ and non-USA300 PVL+ infections were compared. The results of this contemporary, international study suggest that pvl presence was not the primary determinant of outcome in patients with cSSSI due to either MRSA or MSSA.

DOI http://dx.doi.org/10.1371/journal.pone.0037212   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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