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The anaemia of Plasmodium vivax malaria

Douglas, Nicholas M., Anstey, Nicholas M., Buffet, Pierre A., Poespoprodjo, Jeanne R., Yeo, Tsin W., White, Nicholas J. and Price, Ric N. (2012). The anaemia of Plasmodium vivax malaria. Malaria Journal,11(135):1-14.

Document type: Journal Article
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IRMA ID bsmithxPUB74
Title The anaemia of Plasmodium vivax malaria
Author Douglas, Nicholas M.
Anstey, Nicholas M.
Buffet, Pierre A.
Poespoprodjo, Jeanne R.
Yeo, Tsin W.
White, Nicholas J.
Price, Ric N.
Journal Name Malaria Journal
Publication Date 2012
Volume Number 11
Issue Number 135
ISSN 1475-2875   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84862234371
Start Page 1
End Page 14
Total Pages 14
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Plasmodium vivax threatens nearly half the world’s population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia. This review synthesizes current evidence on the epidemiology, pathogenesis, treatment and consequences of vivax-associated anaemia. Young children are at high risk of clinically significant and potentially severe vivax-associated anaemia, particularly in countries where transmission is intense and relapses are frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium vivax causes similar absolute reduction in red blood cell mass because it results in proportionately greater removal of uninfected red blood cells. Severe vivax anaemia is associated with substantial indirect mortality and morbidity through impaired resilience to co-morbidities, obstetric complications and requirement for blood transfusion. Anaemia can be averted by early and effective anti-malarial treatment.
Keywords Plasmodim vivax
Malaria
Anaemia
Epidemiology
Pathogenesis
DOI http://dx.doi.org/10.1186/1475-2875-11-135   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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