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Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children

Rubach, Matthew P., Mukemba, Jackson, Salvatore, Florence, John, Bernard, Crookston, Benjamin, Lopansri, Bert K., Yeo, Tsin W., Piera, Kim A., Alder, Stephen C., Weinberg, J. Brice, Anstey, Nicholas M., Granger, Donald L. and Mwaikambo, Esther D. (2012). Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One,7(5):e35985.

Document type: Journal Article
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IRMA ID cmartelxPUB16
Title Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children
Author Rubach, Matthew P.
Mukemba, Jackson
Salvatore, Florence
John, Bernard
Crookston, Benjamin
Lopansri, Bert K.
Yeo, Tsin W.
Piera, Kim A.
Alder, Stephen C.
Weinberg, J. Brice
Anstey, Nicholas M.
Granger, Donald L.
Mwaikambo, Esther D.
Journal Name PLoS One
Publication Date 2012
Volume Number 7
Issue Number 5
ISSN 1932-6203   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84860631605
Start Page e35985
Total Pages 5
Place of Publication United States
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) concentrations, a measure of parasite biomass, have been correlated with malaria severity in adults, but not yet in children. We measured plasma PfHRP-2 in Tanzanian children with uncomplicated (n = 61) and cerebral malaria (n = 45; 7 deaths). Median plasma PfHRP-2 concentrations were higher in cerebral malaria (1008 [IQR 342–2572] ng/mL) than in uncomplicated malaria (465 [IQR 36–1426] ng/mL; p = 0.017). In cerebral malaria, natural log plasma PfHRP-2 was associated with coma depth (r = −0.42; p = 0.006) and mortality (OR: 3.0 [95% CI 1.03–8.76]; p = 0.04). In this relatively small cohort study in a mesoendemic transmission area of Africa, plasma PfHRP-2 was associated with pediatric malaria severity and mortality. Further studies among children in areas of Africa with higher malaria transmission and among children with different clinical manifestations of severe malaria will help determine the wider utility of quantitative PfHRP-2 as a measure of parasite biomass and prognosis in sub-Saharan Africa.

DOI http://dx.doi.org/10.1371/journal.pone.0035985   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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