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Presence of Genes Encoding Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome in Patients with Hospital-Acquired Pneumonia Due to Staphylococcus aureus

Sharma-Kuinkel, Batu K., Ahn, Sun H., Rude, Thomas H., Zhang, Yurong, Tong, Steven Y. C., Ruffin, Felicia, Genter, Fredric C., Braughton, Kevin R., DeLeo, Frank R., Barriere, Steven L. and Fowler, Vance G., Jr. (2012). Presence of Genes Encoding Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome in Patients with Hospital-Acquired Pneumonia Due to Staphylococcus aureus. Journal of Clinical Microbiology,50(3):848-856.

Document type: Journal Article
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NHMRC Grant No. 508829
Title Presence of Genes Encoding Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome in Patients with Hospital-Acquired Pneumonia Due to Staphylococcus aureus
Author Sharma-Kuinkel, Batu K.
Ahn, Sun H.
Rude, Thomas H.
Zhang, Yurong
Tong, Steven Y. C.
Ruffin, Felicia
Genter, Fredric C.
Braughton, Kevin R.
DeLeo, Frank R.
Barriere, Steven L.
Fowler, Vance G., Jr.
Journal Name Journal of Clinical Microbiology
Publication Date 2012
Volume Number 50
Issue Number 3
ISSN 0095-1137   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84863121284
Start Page 848
End Page 856
Total Pages 9
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract The impact of Panton-Valentine leukocidin (PVL) on the outcome in Staphylococcus aureus pneumonia is controversial. We genotyped S. aureus isolates from patients with hospital-acquired pneumonia (HAP) enrolled in two registrational multinational clinical trials for the genetic elements carrying pvl and 30 other virulence genes. A total of 287 isolates (173 methicillin-resistant S. aureus [MRSA] and 114 methicillin-susceptible S. aureus [MSSA] isolates) from patients from 127 centers in 34 countries for whom clinical outcomes of cure or failure were available underwent genotyping. Of these, pvl was detected by PCR and its product confirmed in 23 isolates (8.0%) (MRSA, 18/173 isolates [10.4%]; MSSA, 5/114 isolates [4.4%]). The presence of pvl was not associated with a higher risk for clinical failure (4/23 [17.4%] versus 48/264 [18.2%]; P = 1.00) or mortality. These findings persisted after adjustment for multiple potential confounding variables. No significant associations between clinical outcome and (i) presence of any of the 30 other virulence genes tested, (ii) presence of specific bacterial clone, (iii) levels of alpha-hemolysin, or (iv) delta-hemolysin production were identified. This study suggests that neither pvl presence nor in vitro level of alpha-hemolysin production is the primary determinant of outcome among patients with HAP caused by S. aureus.
DOI http://dx.doi.org/10.1128/JCM.06219-11   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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