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Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada

Maple-Brown, Louise J., Cunningham, Joan, Zinman, Bernard, Mamakeesick, Mary, Harris, Stewart B., Connelly, Philip W., Shaw, Jonathan, O'Dea, Kerin and Hanley, Anthony J. (2012). Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada. Cardiovascular Diabetology,11(30):1-10.

Document type: Journal Article
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Title Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada
Author Maple-Brown, Louise J.
Cunningham, Joan
Zinman, Bernard
Mamakeesick, Mary
Harris, Stewart B.
Connelly, Philip W.
Shaw, Jonathan
O'Dea, Kerin
Hanley, Anthony J.
Journal Name Cardiovascular Diabetology
Publication Date 2012
Volume Number 11
Issue Number 30
ISSN 1475-2840   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84858970242
Start Page 1
End Page 10
Total Pages 10
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recent comprehensive studies of diabetes complications in different Indigenous populations in Australia and Canada.

Methods
We compared participants from three recent studies: remote Indigenous Australians (2002-2003, n = 37 known diabetes), urban Indigenous Australians (2003-2005, n = 99 known diabetes), and remote Aboriginal Canadians (2001-2002, n = 188 known diabetes).

Results
The three groups were similar for HbA1c, systolic BP, diabetes duration. Although leaner by body-mass-index criteria, remote Indigenous Australians displayed a more adverse CVD risk profile with respect to: waist-hip-ratio (1.03, 0.99, 0.94, remote Indigenous Australians, urban Indigenous Australians, remote Canadians, p < 0.001); HDL-cholesterol (0.82, 0.96, 1.17 mmol/L, p < 0.001); urine albumin-creatinine-ratio (10.3, 2.4, 4.5 mg/mmol); and C-reactive protein. With respect to diabetes complications, microalbuminuria (50%, 25%, 41%, p = 0.001) was more common among both remote groups than urban Indigenous Australians, but there were no differences for peripheral neuropathy, retinopathy or peripheral vascular disease.

Conclusions

Although there are many similarities in diabetes phenotype in Indigenous populations, this comparison demonstrates that CVD risk profiles and diabetes complications may differ among groups. Irrespective, management and intervention strategies are required from a young age in Indigenous populations and need to be designed in consultation with communities and tailored to community and individual needs.
Keywords Aboriginal
Retinopathy
Albuminuria
Peripheral neuropathy
Perhipheral vascular disease
DOI http://dx.doi.org/10.1186/1475-2840-11-30   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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