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Review: Murray Valley encephalitis: a review of clinical features diagnosis and treatment

Knox, James, Cowan, Raquel U., Doyle, Joseph S., Ligtermoet, Matthew K., Archer, John S., Burrow, James N. C., Tong, Steven Y. C., Currie, Bart J., MacKenzie, John S., Smith, David W., Catton, Mike, Moran, Rodney J., Aboltins, Craig A. and Richards, Jack S. (2012). Review: Murray Valley encephalitis: a review of clinical features diagnosis and treatment. Medical Journal of Australia,196(5):322-326.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 27
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Title Review: Murray Valley encephalitis: a review of clinical features diagnosis and treatment
Author Knox, James
Cowan, Raquel U.
Doyle, Joseph S.
Ligtermoet, Matthew K.
Archer, John S.
Burrow, James N. C.
Tong, Steven Y. C.
Currie, Bart J.
MacKenzie, John S.
Smith, David W.
Catton, Mike
Moran, Rodney J.
Aboltins, Craig A.
Richards, Jack S.
Journal Name Medical Journal of Australia
Publication Date 2012
Volume Number 196
Issue Number 5
ISSN 0025-729X   (check CDU catalogue open catalogue search in new window)
Start Page 322
End Page 326
Total Pages 5
Place of Publication Australia
Publisher Australasian Medical Publishing Company Pty. Ltd.
HERDC Category C2 - Journal Article - Other contributions to refereed journal (internal)
Abstract Murray Valley encephalitis virus (MVEV) is a mosquito-borne virus that is found across Australia, Papua New Guinea and Irian Jaya.MVEV is endemic to northern Australia and causes occasional outbreaks across south-eastern Australia.2011 saw a dramatic increase in MVEV activity in endemic regions and the re-emergence of MVEV in south-eastern Australia.This followed significant regional flooding and increased numbers of the main mosquito vector, Culex annulirostris, and was evident from the widespread seroconversion of sentinel chickens, fatalities among horses and several cases in humans, resulting in at least three deaths.The last major outbreak in Australia was in 1974, during which 58 cases were identified and the mortality rate was about 20%.With the potential for a further outbreak of MVEV in the 2011–2012 summer and following autumn, we highlight the importance of this disease, its clinical characteristics and radiological and laboratory features.We present a suspected but unproven case of MVEV infection to illustrate some of the challenges in clinical management.It remains difficult to establish an early diagnosis of MVEV infection, and there is a lack of proven therapeutic options.
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