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Characterisation of a G9P[8] rotavirus strain identified during a gastroenteritis outbreak in Alice Springs, Australia post RotarixTM vaccine introduction

Donato, C. M., Cannan, D., Bogdanovic-Sakran, N., Snelling, Thomas L. and Kirkwood, C. D. (2012). Characterisation of a G9P[8] rotavirus strain identified during a gastroenteritis outbreak in Alice Springs, Australia post RotarixTM vaccine introduction. Vaccine,30(Supplement 1):A152-A158.

Document type: Journal Article

IRMA ID MENbsnellxPUB69
Title Characterisation of a G9P[8] rotavirus strain identified during a gastroenteritis outbreak in Alice Springs, Australia post RotarixTM vaccine introduction
Author Donato, C. M.
Cannan, D.
Bogdanovic-Sakran, N.
Snelling, Thomas L.
Kirkwood, C. D.
Journal Name Vaccine
Publication Date 2012
Volume Number 30
Issue Number Supplement 1
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84859953371
Start Page A152
End Page A158
Place of Publication Guildford
Publisher Butterworths
HERDC Category C1 - Journal Article (DIISR)
Abstract A large rotavirus gastroenteritis outbreak occurred in the Alice Springs region of the Northern Territory, Australia from the 12th of March until the 11th of July 2007. The outbreak occurred five months after the introduction of the Rotarix™ vaccine. Electropherotype and sequence analysis demonstrated that a single G9P[8] strain was responsible for the outbreak and that the strain remained highly conserved during the outbreak period. The outbreak strain contained amino acid changes in regions of the VP7 and NSP4 genes, with known biological function, when compared to previously characterised G9P[8] strains from Australia and other international locations. The recent vaccine introduction was unlikely to have influenced genotype selection in this setting. Importantly, Rotarix™ vaccine was highly effective against the G9P[8] outbreak strain.
Keywords Rotavirus
Gastroenteritis
Rotarix™
G9P[8]
Australia
DOI http://dx.doi.org/10.1016/j.vaccine.2011.07.119   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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