Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Plasmodium knowlesi malaria : epidemiology, clinical features, diagnosis and pathogenesis, diagnosis and pathogenesis

Barber, Bridget (2013). Plasmodium knowlesi malaria : epidemiology, clinical features, diagnosis and pathogenesis, diagnosis and pathogenesis. PhD Thesis, Charles Darwin University.

Document type: Thesis
Citation counts: Google Scholar Search Google Scholar
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Thesis_CDU_39023_Barber_B.pdf PDF version generated by student application/pdf 3.51MB 489
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

Author Barber, Bridget
Title Plasmodium knowlesi malaria : epidemiology, clinical features, diagnosis and pathogenesis, diagnosis and pathogenesis
Institution Charles Darwin University
Publication Date 2013
Thesis Type PhD
Subjects 1117 - Public Health and Health Services
1199 - Other Medical and Health Sciences
Abstract The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo, and can cause severe and fatal disease. Substantial knowledge gaps exist in regards to the epidemiology, clinical features, diagnosis, and pathophysiology of knowlesi malaria, and the overall aim of this thesis was to enhance understanding in these areas.

First, two retrospective studies were conducted at Kudat District Hospital, northeast Sabah, with these studies confirming that P. knowlesi was the most common cause of malaria among adults and children at this hospital. A wide age-distribution among patients with knowlesi malaria was described, and two family clusters were identified. Second, Sabah Department of Health malaria notification data were reviewed, with this study demonstrating that, while notifications of P. falciparum and P. vivax had decreased markedly over the past 20 years, over the past decade notifications of “P. malariae/P. knowlesi” increased significantly. Third, a prospective observational study was conducted, involving all malaria patients admitted to Queen Elizabeth Hospital (QEH), a tertiary-referral hospital in Sabah, from September 2010 to October 2011. This study found that P. knowlesi was the most common cause of severe malaria at QEH, and was associated with a 3-fold increased risk of severity compared to P. falciparum. Parasite count was the major independent risk factor for severe knowlesi malaria, with risk increasing 11-fold with parasitemia >20,000/μL and 28-fold with parasitemia >100,000/μL. Artesunate therapy was highly effective for severe malaria, and no deaths from any species occurred in this study. This study also evaluated the accuracy of microscopy, and the sensitivity of two rapid diagnostic tests, for the diagnosis of knowlesi malaria. Finally, in the first of a series of pathophysiological studies conducted at QEH, red cell deformability among patients with knowlesi malaria was investigated. These studies have confirmed the importance of knowlesi malaria as a public health problem in Sabah, and have extended the existing information regarding the epidemiological and clinical features, as well as diagnosis and treatment, of knowlesi malaria. Future research priorities are identified in order to enhance our understanding of this emerging disease.
Additional Notes Please note that published article : Barber BE, William T, Grigg MJ, Menon J, Auburn S, Marfurt J, Anstey NM, Yeo TW. 'A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy'. Clinical Infectious Diseases 2013; 56(3):383-97 - listed in "Published manuscripts forming the basis of this thesis" on page xvi, is only available on CD ROM.


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 302 Abstract Views, 491 File Downloads  -  Detailed Statistics
Created: Fri, 06 Jun 2014, 10:23:25 CST