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Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individuals at high cardiovascular risk: The SPACE Collaboration

Webster, Ruth, Patel, Anushka, Billot, Laurent, Cass, Alan, Burch, Carol, Neal, Bruce, Usherwood, Tim, Thom, Simon, Poulter, Neil, Stanton, Alice, Bots, Michiel, Grobbee, Diederick, Prabhakara, Dorairaj, Reddy, K. Srinath, Field, Jane, Bullen, Chris, Elley, C. Raina, Selak, Vanessa, Rafter, Natasha, Wadham, Angela and et al. (2013). Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individuals at high cardiovascular risk: The SPACE Collaboration. International Journal of Cardiology,170(1):30-35.

Document type: Journal Article

IRMA ID 11035xPUB43
Title Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individuals at high cardiovascular risk: The SPACE Collaboration
Author Webster, Ruth
Patel, Anushka
Billot, Laurent
Cass, Alan
Burch, Carol
Neal, Bruce
Usherwood, Tim
Thom, Simon
Poulter, Neil
Stanton, Alice
Bots, Michiel
Grobbee, Diederick
Prabhakara, Dorairaj
Reddy, K. Srinath
Field, Jane
Bullen, Chris
Elley, C. Raina
Selak, Vanessa
Rafter, Natasha
Wadham, Angela
et al.
Journal Name International Journal of Cardiology
Publication Date 2013
Volume Number 170
Issue Number 1
ISSN 0167-5273   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84888003452
Start Page 30
End Page 35
Total Pages 6
Place of Publication Ireland
Publisher Elsevier Ireland Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract BACKGROUND:
An international collaboration of investigators will assess the benefits and risks of fixed dose combination (FDC) based care compared with usual care in populations at high risk of cardiovascular disease (CVD). Several trials are being conducted, as the effectiveness and economic impact of a FDC-based strategy may vary substantially between countries, given the varying influence of the health-care system within which the intervention is delivered.

METHODS:

Individual patient data (IPD) will be provided by participating trials for combined IPD meta-analysis.

RESULTS:

Primary outcomes will include self-reported current use of antiplatelet, statin, and combination (≥ 2) blood pressure lowering therapies at 12 months, and change in systolic blood pressure (SBP) and LDL cholesterol from baseline to 12 months. Non-inferiority margins of 3 mm Hg for SBP and 0.3 mmol/L for LDL cholesterol have been pre-specified. Secondary outcomes will include change in cholesterol fractions, diastolic blood pressure and creatinine from baseline to 12 months, quality of life, new onset diabetes mellitus, mortality (cardiovascular, non-cardiovascular and all cause) and a composite outcome of cardiovascular events (including all coronary heart disease events, heart failure events leading to death or requiring hospital admission, cerebrovascular events and peripheral arterial events).

CONCLUSION:

The SPACE group of trials will assess, in a variety of healthcare settings, whether a FDC strategy for delivery of preventive medication has the potential to significantly improve prevention of cardiovascular disease in patients at high risk.
DOI http://dx.doi.org/10.1016/j.ijcard.2013.10.007   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Thu, 07 Aug 2014, 16:56:28 CST