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Paracellular Absorption Is Relatively Low in the Herbivorous Egyptian Spiny-Tailed Lizard, Uromastyx aegyptia

McWhorter, Todd J., Pinshow, Berry, Karasov, William H. and Tracy, Christopher R. (2013). Paracellular Absorption Is Relatively Low in the Herbivorous Egyptian Spiny-Tailed Lizard, Uromastyx aegyptia. PLoS One,8(4):e61869-1-e61869-9.

Document type: Journal Article
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ARC Grant No. LP0882478
IRMA ID 82057923xPUB468
Title Paracellular Absorption Is Relatively Low in the Herbivorous Egyptian Spiny-Tailed Lizard, Uromastyx aegyptia
Author McWhorter, Todd J.
Pinshow, Berry
Karasov, William H.
Tracy, Christopher R.
Journal Name PLoS One
Publication Date 2013
Volume Number 8
Issue Number 4
ISSN 1932-6203   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84876185907
Start Page e61869-1
End Page e61869-9
Total Pages 9
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract Absorption of small water-soluble nutrients in vertebrate intestines occurs both by specific, mediated transport and by non-specific, passive, paracellular transport. Although it is apparent that paracellular absorption represents a significant route for nutrient absorption in many birds and mammals, especially small, flying species, its importance in ectothermic vertebrates has not previously been explored. Therefore, we measured fractional absorption (ƒ) and absorption rate of three paracellular probes (arabinose, l-rhamnose, cellobiose) and of 3-O-methyl d-glucose (absorbed by both mediated and paracellular pathways) by the large herbivorous lizard, Uromastyx aegyptia, to explore the relative importance of paracellular and mediated transport in an ectothermic, terrestrial vertebrate. Fractional absorption of 3-O-methyl d-glucose was high (ƒ = 0.73±0.04) and similar to other vertebrates; ƒ of the paracellular probes was relatively low (arabinose ƒ = 0.31±0.03, l-rhamnose ƒ = 0.19±0.02, and cellobiose ƒ = 0.14±0.02), and decreased with molecular mass, a pattern consistent with other vertebrates. Paracellular absorption accounted for approximately 24% of total 3-O-methyl d-glucose uptake, indicating low reliance on this pathway for these herbivorous lizards, a pattern similar to that found in other terrestrial vertebrates, and different from small flying endotherms (both birds and bats).

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Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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