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Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea

Kim, Jung-Yeon, Ji, So-Young, Goo, Youn-Kyoung, Na, Byoung-Kuk, Pyo, Hyo-Joo, Lee, Han-Na, Lee, Juyoung, Kim, Nam Hee, von Seidlein, Lorenz, Cheng, Qin, Cho, Shin-Hyung and Lee, Won-Ja (2013). Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea. PLoS One,8(5):e64353-1-e64353-6.

Document type: Journal Article
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Title Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea
Author Kim, Jung-Yeon
Ji, So-Young
Goo, Youn-Kyoung
Na, Byoung-Kuk
Pyo, Hyo-Joo
Lee, Han-Na
Lee, Juyoung
Kim, Nam Hee
von Seidlein, Lorenz
Cheng, Qin
Cho, Shin-Hyung
Lee, Won-Ja
Journal Name PLoS One
Publication Date 2013
Volume Number 8
Issue Number 5
ISSN 1932-6203   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84877111022
Start Page e64353-1
End Page e64353-6
Total Pages 6
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStartTM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStartTM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/μl, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria.

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Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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