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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: A workshop report

von Seidlein, Lorenz, Auburn, Sarah, Espino, Fe, Shanks, Dennis, Cheng, Qin, McCarthy, James, Baird, Kevin, Moyes, Catherine, Howes, Rosalind, Menard, Didier, Bancone, Germana, Winasti-Satuahraha, Ari, Vestergaard, Lasse S., Green, Justin, Domingo, Gonzalo, Yeung, Shunmay and Price, Ric N. (2013). Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: A workshop report. Malaria Journal,12:112-1-112-12.

Document type: Journal Article
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Title Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: A workshop report
Author von Seidlein, Lorenz
Auburn, Sarah
Espino, Fe
Shanks, Dennis
Cheng, Qin
McCarthy, James
Baird, Kevin
Moyes, Catherine
Howes, Rosalind
Menard, Didier
Bancone, Germana
Winasti-Satuahraha, Ari
Vestergaard, Lasse S.
Green, Justin
Domingo, Gonzalo
Yeung, Shunmay
Price, Ric N.
Journal Name Malaria Journal
Publication Date 2013
Volume Number 12
ISSN 1475-2875   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84875345746
Start Page 112-1
End Page 112-12
Total Pages 12
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving the radical cure of Plasmodium vivax. 8-aminoquinolines, such as primaquine, can induce severe haemolysis in G6PD-deficient individuals, potentially creating significant morbidity and undermining confidence in 8-aminoquinoline prescription. On the other hand, erring on the side of safety and excluding large numbers of people with unconfirmed G6PD deficiency from treatment with 8-aminoquinolines will diminish the impact of these drugs. Estimating the remaining G6PD enzyme activity is the most direct, accessible, and reliable assessment of the phenotype and remains the gold standard for the diagnosis of patients who could be harmed by the administration of primaquine. Genotyping seems an unambiguous technique, but its use is limited by cost and the large range of recognized G6PD genotypes. A number of enzyme activity assays diagnose G6PD deficiency, but they require a cold chain, specialized equipment, and laboratory skills. These assays are impractical for care delivery where most patients with malaria live. Improvements to the diagnosis of G6PD deficiency are required for the broader and safer use of 8-aminoquinolines to kill hypnozoites, while lower doses of primaquine may be safely used to kill gametocytes without testing. The discussions and conclusions of a workshop conducted in Incheon, Korea in May 2012 to review key knowledge gaps in G6PD deficiency are reported here.
Keywords Malaria
Vivax
Falciparum
8-aminoquinolines
Primaquine
Tafenoquine
G6PD
Deficiency
Diagnostic tests
DOI http://dx.doi.org/10.1186/1475-2875-12-112   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Open access True
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/au/legalcode


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