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Vivax malaria and bacteraemia: a prospective study in Kolkata, India

Bhattacharya, Sujit Kumar, Sur, Dipika, Dutta, Shanta, Kanungo, Suman, Ochiai, R. Loen, Kim, Deok Ryun, Anstey, Nicholas M., von Seidlein, Lorenz and Deen, Jacqueline L. (2013). Vivax malaria and bacteraemia: a prospective study in Kolkata, India. Malaria Journal,12:176-1-176-4.

Document type: Journal Article
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Title Vivax malaria and bacteraemia: a prospective study in Kolkata, India
Author Bhattacharya, Sujit Kumar
Sur, Dipika
Dutta, Shanta
Kanungo, Suman
Ochiai, R. Loen
Kim, Deok Ryun
Anstey, Nicholas M.
von Seidlein, Lorenz
Deen, Jacqueline L.
Journal Name Malaria Journal
Publication Date 2013
Volume Number 12
ISSN 1475-2875   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84878361976
Start Page 176-1
End Page 176-4
Total Pages 4
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Falciparum malaria increases the risk for bacteraemia, whereas the relationship between vivax malaria and bacteraemia is not clear. Data from a prospective fever surveillance study in Kolkata, India were reanalysed for the potential association between Plasmodium vivax malaria and bacteraemia.

Methods
Patients of all ages presenting with fever of three days or more to a project health outpost were invited to participate. A blood film and blood culture was performed on presentation. Treatment and referral were provided according to national guidelines. The case fraction and incidence of malaria, bacteraemia, and co-infection were calculated.

Results
3,371 participants were enrolled during a one-year study period, of whom 93/3,371 (2.8%) had malaria (89/93 [95.7%] Plasmodium vivax) and 256 (7.6%) bacteraemia. There were 154 malaria, 423 bacteraemia and 10 P. vivax-bacteremia coinfection episodes per 100,000/year. Among the malaria-bacteraemia co-infections, all were vivax malaria and 5/6 (83%) bacteria isolated were Gram-negative (one S. Typhi, one S. Paratyphi A, three other Gram-negative). Bacteraemia occurred in 6/89 (6.7% [95%CI: 3.1-13.9%]) of P. vivax cases versus 250/3,278 (7.6% [95% CI: 6.7-8.6%]) without Plasmodium infection (p=0.76).

Conclusions
While an increased risk was not demonstrated, concomitant bacteraemia occurs frequently in vivax malaria in an area with a high background incidence of bacteraemia, and should be considered in cases of vivax malaria with severe manifestations.


Keywords Bacteraemia
Falciparum malaria
Vivax malaria
DOI http://dx.doi.org/10.1186/1475-2875-12-176   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/au/legalcode


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