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Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012

Lai, Jana, Cook, Heather, Yip, Teem-Wing, Berthelsen, Jeanette, Gourley, Stephen, Krause, Vicki, Smith, Helen, Leach, Amanda J. and Smith-Vaughan, Heidi C. (2013). Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012. BMC Infectious Diseases,13:409-1-409-7.

Document type: Journal Article
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IRMA ID cmartelxPUB115
NHMRC Grant No. 545232
1024175
1020561
Title Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012
Author Lai, Jana
Cook, Heather
Yip, Teem-Wing
Berthelsen, Jeanette
Gourley, Stephen
Krause, Vicki
Smith, Helen
Leach, Amanda J.
Smith-Vaughan, Heidi C.
Journal Name BMC Infectious Diseases
Publication Date 2013
Volume Number 13
ISSN 1471-2334   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84883266354
Start Page 409-1
End Page 409-7
Total Pages 1
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
An outbreak of serotype 1 invasive pneumococcal disease (IPD) occurred in Central Australia from October 2010 to the latter part of 2012. Surveillance of serotype 1 carriage was conducted to determine epidemiological features of asymptomatic carriage that could potentially be driving the outbreak.

Methods
130 patients and accompanying persons presenting at Alice Springs Hospital Emergency Department consented to nasopharyngeal swab (NPS) collection. NPS were processed by standard methods, including culture, pneumococcal lytA quantitative real-time PCR, serotype 1-specific real-time PCR and multi-locus sequence typing (MLST).

Results
Pneumococcal carriage was detected in 16% of participants. Carriage was highest in the under 10 year olds from remote communities surrounding Alice Springs (75%). Four NPS were positive for serotype 1 DNA by PCR; 3 were also culture-positive for serotype 1 pneumococci. Serotype 1 isolates had atypical colony morphology on primary culture. All serotype 1 carriers were healthy children 5 to 8 years of age from remote communities. By MLST, serotype 1 isolates were ST306, as were IPD isolates associated with this outbreak.

Conclusions
During an outbreak of serotype 1 ST306 IPD, carriage of the outbreak strain was detected in 3% NPS collected. All carriers were healthy children 5 to 8 years of age
Keywords Invasive pneumococcal disease
Serotype 1
Central Australia
Carriage
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 3.0 License
Link to published version
URL https://creativecommons.org/licenses/by/3.0/au/legalcode
http://www.biomedcentral.com/1471-2334/13/409/abstract


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