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Cough and exhaled nitric oxide levels: what happens with exercise?

Petsky, Helen L., Kynaston, Jennifer Anne, McElrea, Margaret, Turner, Catherine, Isles, Alan and Chang, Anne B. (2013). Cough and exhaled nitric oxide levels: what happens with exercise?. Frontiers in Pediatrics,1 (Articel 30)(October):30-1-30-7.

Document type: Journal Article
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IRMA ID cmartelxPUB117
Title Cough and exhaled nitric oxide levels: what happens with exercise?
Author Petsky, Helen L.
Kynaston, Jennifer Anne
McElrea, Margaret
Turner, Catherine
Isles, Alan
Chang, Anne B.
Journal Name Frontiers in Pediatrics
Publication Date 2013
Volume Number 1 (Articel 30)
Issue Number October
ISSN 2296-2360   (check CDU catalogue open catalogue search in new window)
Start Page 30-1
End Page 30-7
Total Pages 7
Place of Publication Switzerland
Publisher Frontiers Research Foundation
HERDC Category C1 - Journal Article (DIISR)
Abstract Cough associated with exertion is often used as a surrogate marker of asthma. However, to date there are no studies that have objectively measured cough in association with exercise in children. Our primary aim was to examine whether children with a pre-existing cough have an increase in cough frequency during and post-exercise. We hypothesized that children with any coughing illness will have an increase in cough frequency post-exercise regardless of the presence of exercise-induced broncho-constriction (EIB) or atopy. In addition, we hypothesized that Fractional exhaled nitric oxide (FeNO) levels decreases post-exercise regardless of the presence of EIB or atopy. Children with chronic cough and a control group without cough undertook an exercise challenge, FeNO measurements and a skin prick test, and wore a 24-h voice recorder to objectively measure cough frequency. The association between recorded cough frequency, exercise, atopy, and presence of EIB was tested. We also determined if the change in FeNO post exercise related to atopy or EIB. Of the 50 children recruited (35 with cough, 15 control), 7 had EIB. Children with cough had a significant increase in cough counts (median 7.0, inter-quartile ranges, 0.5, 24.5) compared to controls (2.0, IQR 0, 5.0, p = 0.028) post-exercise. Presence of atopy or EIB did not influence cough frequency. FeNO level was significantly lower post-exercise in both groups but the change was not influenced by atopy or EIB. Cough post-exertion is likely a generic response in children with a current cough. FeNO level decreases post-exercise irrespective of the presence of atopy or EIB. A larger study is necessary confirm or refute our findings.
Keywords Cough
Pediatrics
Exercise-induced broncho-constriction
Atopy
FeNO
DOI http://dx.doi.org/10.3389/fped.2013.00030   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Open access True
Additional Notes This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. This is an Open Access article distributed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 3.0 License
URL https://creativecommons.org/licenses/by/3.0/au/legalcode


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