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Plasmodium vivax Population Structure and Transmission Dynamics in Sabah Malaysia

Abdullah, Noor Rain, Barber, Bridget E., William, Timothy, Norahmad, Nor Azrina, Satsu, Umi Rubiah, Muniandy, Prem Kumar, Ismail, Zakiah, Grigg, Matthew J., Jelip, Jenarun, Piera, Kim, von Seidlein, Lorenz, Yeo, Tsin, Anstey, Nicholas M., Price, Ric N. and Auburn, Sarah (2013). Plasmodium vivax Population Structure and Transmission Dynamics in Sabah Malaysia. PLoS One,8(12):e82553 - 1-e82553 - 10.

Document type: Journal Article
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Title Plasmodium vivax Population Structure and Transmission Dynamics in Sabah Malaysia
Author Abdullah, Noor Rain
Barber, Bridget E.
William, Timothy
Norahmad, Nor Azrina
Satsu, Umi Rubiah
Muniandy, Prem Kumar
Ismail, Zakiah
Grigg, Matthew J.
Jelip, Jenarun
Piera, Kim
von Seidlein, Lorenz
Yeo, Tsin
Anstey, Nicholas M.
Price, Ric N.
Auburn, Sarah
Journal Name PLoS One
Publication Date 2013
Volume Number 8
Issue Number 12
ISSN 1932-6203   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84893086402
Start Page e82553 - 1
End Page e82553 - 10
Total Pages 10
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract Despite significant progress in the control of malaria in Malaysia, the complex transmission dynamics of P. vivax continue to challenge national efforts to achieve elimination. To assess the impact of ongoing interventions on P. vivax transmission dynamics in Sabah, we genotyped 9 short tandem repeat markers in a total of 97 isolates (8 recurrences) from across Sabah, with a focus on two districts, Kota Marudu (KM, n = 24) and Kota Kinabalu (KK, n = 21), over a 2 year period. STRUCTURE analysis on the Sabah-wide dataset demonstrated multiple sub-populations. Significant differentiation (FST = 0.243) was observed between KM and KK, located just 130 Km apart. Consistent with low endemic transmission, infection complexity was modest in both KM (mean MOI = 1.38) and KK (mean MOI = 1.19). However, population diversity remained moderate (HE = 0.583 in KM and HE = 0.667 in KK). Temporal trends revealed clonal expansions reflecting epidemic transmission dynamics. The haplotypes of these isolates declined in frequency over time, but persisted at low frequency throughout the study duration. A diverse array of low frequency isolates were detected in both KM and KK, some likely reflecting remnants of previous expansions. In accordance with clonal expansions, high levels of Linkage Disequilibrium (IAS >0.5 [P<0.0001] in KK and KM) declined sharply when identical haplotypes were represented once (IAS = 0.07 [P = 0.0076] in KM, and IAS = -0.003 [P = 0.606] in KK). All 8 recurrences, likely to be relapses, were homologous to the prior infection. These recurrences may promote the persistence of parasite lineages, sustaining local diversity. In summary, Sabah's shrinking P. vivax population appears to have rendered this low endemic setting vulnerable to epidemic expansions. Migration may play an important role in the introduction of new parasite strains leading to epidemic expansions, with important implications for malaria elimination.

DOI http://dx.doi.org/10.1371/journal.pone.0082553   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Open access True
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au/legalcode


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