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Nasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination

Dunne, Eileen M., Smith-Vaughan, Heidi C., Robins-Browne, Roy, Mulholland, E. Kim and Satzke, Catherine (2013). Nasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination. Vaccine,31(19):2333-2342.

Document type: Journal Article

Title Nasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination
Author Dunne, Eileen M.
Smith-Vaughan, Heidi C.
Robins-Browne, Roy
Mulholland, E. Kim
Satzke, Catherine
Journal Name Vaccine
Publication Date 2013
Volume Number 31
Issue Number 19
Scopus ID 2-s2.0-84876081088
Start Page 2333
End Page 2342
Total Pages 10
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract The nasopharynx of children is often colonised by microorganisms such as Streptococcus pneumoniae (the pneumococcus) that can cause infections including pneumonia and otitis media. In this complex environment, bacteria and viruses may impact each other through antagonistic as well as synergistic interactions. Vaccination may alter colonisation dynamics, evidenced by the rise in non-vaccine serotypes following pneumococcal conjugate vaccination. Discovery of an inverse relationship between S. pneumoniae and Staphylococcus aureus carriage generated concern that pneumococcal vaccination could increase S. aureus carriage and disease. Here we review data on co-colonisation of pathogens in the nasopharynx, focusing on S. pneumoniae and the impact of pneumococcal vaccination. Thus far, pneumococcal vaccination has not had a sustained impact on S. aureus carriage but it is associated with an increase in non-typeable Haemophilus influenzae in acute otitis media aetiology. Advances in bacterial and viral detection methodologies have facilitated research in nasopharyngeal microbiology and will aid investigation of potential vaccine-induced changes, particularly when baseline studies can be conducted prior to pneumococcal vaccine introduction.
Keywords Streptococcus pneumoniae
Microbial interactions
Pneumococcal vaccines
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Created: Thu, 07 Aug 2014, 17:22:41 CST