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An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol

Singh, Jagtar, Jayaraj, Ramamoorthi, Baxi, Siddartha, Mileva, Marina, Curtin, Justin and Thomas, Mahiban (2013). An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol. Asian Pacific Journal of Cancer Prevention,14(8):4717-4721.

Document type: Journal Article
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IRMA ID 82794376xPUB127
Title An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol
Author Singh, Jagtar
Jayaraj, Ramamoorthi
Baxi, Siddartha
Mileva, Marina
Curtin, Justin
Thomas, Mahiban
Journal Name Asian Pacific Journal of Cancer Prevention
Publication Date 2013
Volume Number 14
Issue Number 8
ISSN 1513-7368   (check CDU catalogue  open catalogue search in new window)
Start Page 4717
End Page 4721
Total Pages 5
Place of Publication Thailand
Publisher Asian Pacific Organization for Cancer Prevention
HERDC Category C3 - Journal Article - Non-refereed articles (including articles in professional journals) (internal)
Abstract Complete surgical resection of the primary tumour is a crucial predictive step for head and neck squamous cell carcinoma (HNSCC), because incomplete resection may lead to increase in the recurrence rate. Molecular cancer markers have been investigated as potential predictors of prognosis marker, to identify patients who are at high risk of local recurrence. This retrospective study aimed to determine the prognostic correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival. Forty eight HNSCC patients were selected between 2006 and 2009 diagnosed at the Royal Darwin Hospital, Darwin, Northern Territory, Australia. Out of 48, only those 24 with negative surgical margins with hematoxylin and eosin (HandE) were chosedn for further analysis. A total of 77 surgical margins were obtained and subsequently analysed by immunohistochemical (IHC) staining with monoclonal p53 and polyclonal eIF4E antibodies. Contingency table and χ2-test were used to investigate the correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival of the HNSCC patients. The follow up period was 74 months (range 1-74 months). The Kaplan-Meier method was used to generate recurrence and survival curves. This is a first retrospective study of Northern Territory patients, including Indigenous and non-Indigenous Australians. Molecular study of surgical margins could help to identify patients with and without clear margins after surgery and help in choice of the most appropriate adjuvant treatment for HNSCC patients.
Keywords Head and neck squamous cell carcinoma
eIF4E
Immunohistochemistry
Recurrence
Survival
DOI http://dx.doi.org/10.7314/APJCP.2013.14.8.4717   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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