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Acquisition and Expression of Conditioned Hypoalgesia in Morphine-Naive and Morphine-Tolerant Rats

Foo, Hayley Siew Lan (1999). Acquisition and Expression of Conditioned Hypoalgesia in Morphine-Naive and Morphine-Tolerant Rats. Pharmacology Biochemistry and Behavior,62(3):433-437.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 2 times in Scopus Article | Citations

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Title Acquisition and Expression of Conditioned Hypoalgesia in Morphine-Naive and Morphine-Tolerant Rats
Author Foo, Hayley Siew Lan
Journal Name Pharmacology Biochemistry and Behavior
Publication Date 1999
Volume Number 62
Issue Number 3
ISSN 0091-3057   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-0033015508
Start Page 433
End Page 437
Total Pages 5
Place of Publication United States of America
Publisher Elsevier Inc.
Field of Research 270000 Biological Sciences
Abstract The present study used a within-subject design to examine acquisition and expression of conditioned hypoalgesia in 50 male Wistar rats. Morphine-naive rats preexposed to a heat stressor with saline were hypoalgesic when subsequently tested for latencies to tail flick or paw lick. However, morphine-tolerant rats preexposed to the heat stressor with saline failed to display hypoalgesia when tested for latencies to tail flick, but showed hypoalgesia when tested for latencies to paw lick. Taken together, these findings suggest that expression of conditioned hypoalgesic responses in morphine-tolerant rats may depend on the nociceptive test used. Both morphine-naive and morphine-tolerant rats preexposed to the heat stressor with morphine failed to display hypoalgesia on either the tail-flick or the hot-plate test, demonstrating that morphine’s ability to block acquisition of conditioned hypoalgesia is independent of the test used to assess nociceptive sensitivity.
Keywords Hot plate
Hypoalgesia
Morphine
Stressor
Tail flick
DOI http://dx.doi.org/10.1016/S0091-3057(98)00189-0   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Fri, 29 Aug 2014, 19:58:44 CST by Anthony Hornby