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A high incidence of melanoma found in patients with multiple dysplastic naevi by photographic surveillance

Kelly, John W., Yeatman, Josephine M., Regalia, Cheryl, Mason, Grahame and Henham, Amanda P. (1997). A high incidence of melanoma found in patients with multiple dysplastic naevi by photographic surveillance. Medical Journal of Australia,167(4):191-194.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 113 times in Scopus Article | Citations
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Title A high incidence of melanoma found in patients with multiple dysplastic naevi by photographic surveillance
Author Kelly, John W.
Yeatman, Josephine M.
Regalia, Cheryl
Mason, Grahame
Henham, Amanda P.
Journal Name Medical Journal of Australia
Publication Date 1997-08-18
Volume Number 167
Issue Number 4
ISSN 0025-729X   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-0030885368
Start Page 191
End Page 194
Total Pages 4
Place of Publication Australia
Publisher Australasian Medical Publishing Company Pty. Ltd.
Abstract Objectives:
(1) To assess the incidence of melanoma in a cohort of patients with dysplastic melanocytic naevi (DMN) and the relationships between incident melanomas and preexisting naevi and between melanoma risk and numbers of DMN. (2) To examine the role of the patient versus the physician in detecting melanoma and the relative value of surveillance versus prophylactic excision.

Design:
Prospective cohort study.

Patients and setting:
Two hundred and seventy-eight adults, each with five or more DMN, were followed up for a mean period of 42 months in a private dermatology practice. DMN were clinically diagnosed.
Results: Twenty new melanomas were detected in 16 patients, corresponding to an age-adjusted incidence of 1835/100 000 person-years, 46 times the incidence in the general population. Eleven were detected because of changes evident in comparison with baseline photographs and nine were detected by patients or their partners. Thirteen of the 20 melanomas arose as new lesions and only three from DMN. Melanoma risk rose with increasing numbers of DMN.

Conclusions:
Increasing numbers of DMN are associated with increasing melanoma risk. Surveillance (baseline photography and follow-up) enabled early diagnosis of melanoma and was very much more cost-effective in preventing life-threatening melanoma than prophylactic excision of DMN.
Description for Link Link to published version
URL https://www.mja.com.au/journal/1997/167/4/high-incidence-melanoma-found-patients-multiple-dysplastic-naevi-photographic
 
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Created: Fri, 29 Aug 2014, 20:10:29 CST by Anthony Hornby