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Cough, airway inflammation, and mild asthma exacerbation

Chang, Anne B., Harrhy, V. A., Simpson, John, Masters, Ian B. and Gibson, P. G. (2002). Cough, airway inflammation, and mild asthma exacerbation. Archives of Disease in Childhood,86(4):270-275.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 9
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Title Cough, airway inflammation, and mild asthma exacerbation
Author Chang, Anne B.
Harrhy, V. A.
Simpson, John
Masters, Ian B.
Gibson, P. G.
Journal Name Archives of Disease in Childhood
Publication Date 2002
Volume Number 86
Issue Number 4
ISSN 1468-2044   (check CDU catalogue open catalogue search in new window)
Start Page 270
End Page 275
Total Pages 6
Place of Publication UK
Publisher B M J Group
HERDC Category C1 - Journal Article (DEST)
Abstract BACKGROUND: Prospective data on the temporal relation between cough, asthma symptoms, and airway inflammation in childhood asthma is unavailable. AIMS AND METHODS: Using several clinical (diary, quality of life), lung function (FEV(1), FEV(1) variability, airway hyperresponsiveness), cough (diary, cough receptor sensitivity (CRS)), and inflammatory markers (sputum interleukin 8, eosinophilic cationic protein (ECP), myeloperoxidase; and serum ECP) of asthma severity, we prospectively described the course of these markers in children with asthma during a non-acute, acute, and resolution phase. A total of 21 children with asthma underwent these baseline tests; 11 were retested during days 1, 3, 7, and 28 of an exacerbation. RESULTS: Asthma exacerbations were characterised by increased asthma and cough symptoms and eosinophilic inflammation. Sputum ECP showed the largest increase and peaked later than clinical scores. Asthma scores consistently related to cough score only early in the exacerbation. Neither CRS nor cough scores related to any inflammatory marker. CONCLUSION: In mild asthma exacerbations, eosinophilic inflammation is dominant. In asthmatic children who cough as a dominant symptom, cough heralds the onset of an exacerbation and increased eosinophilic inflammation, but cough scores and CRS do not reflect eosinophilic airway inflammation.
Keywords airway
DOI   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 3988 (Journal) DA - 20020328IS - 1468-2044 (Electronic)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tSB - AIMSB - IM
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Created: Mon, 17 Dec 2007, 09:02:11 CST