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Anticholinergics for prolonged non-specific cough in children (Review)

Chang, Anne B., McKean, Michael C. and Morris, Peter S. (2003). Anticholinergics for prolonged non-specific cough in children (Review)<br />. Cochrane Database of Systematic Reviews,2003(4 - Article No. CD004358).

Document type: Journal Article
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Title Anticholinergics for prolonged non-specific cough in children (Review)
Author Chang, Anne B.
McKean, Michael C.
Morris, Peter S.
Journal Name Cochrane Database of Systematic Reviews
Publication Date 2003
Volume Number 2003
Issue Number 4 - Article No. CD004358
ISSN 1469-493X   (check CDU catalogue open catalogue search in new window)
Total Pages 12
Place of Publication United Kingdom
Publisher John Wiley & Sons Ltd.
Language English
HERDC Category C1 - Journal Article (DEST)
Abstract Background
Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including inhaled anti-cholinergic medications.


To determine the efficacy of inhaled anti-cholinergic medications in the management of prolonged non-specific cough in children.

Search methods

The Cochrane Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE databases were searched. Relevant pharmaceutical companies were contacted. The latest searches were carried out in April 2010.

Selection criteria

All randomised controlled trials comparing inhaled anti-cholinergic medication with a placebo medication.

Data collection and analysis

Results of searches were reviewed against pre-determined criteria for inclusion. No eligible trials were identified and thus no data were available for analysis. A single small trial in adults has been reported.

Main results

No randomised-controlled trials that examined the efficacy of inhaled anti-cholinergic medications in the management of prolonged non-specific cough in children were found. An additional search in April 2010 did not identify any further studies.

Authors' conclusions

There is currently no evidence to support the use of inhaled anti-cholinergics for symptomatic control of non-specific cough in children. Further research examining the effects of this intervention is needed.
Keywords Anticholinergics
DOI   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)

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