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A bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation

Chang, Anne B., Faoagali, J., Cox, N., Marchant, J., Dean, B., Petsky, H. and Masters, Ian B. (2006). A bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation. Pediatric Pulmonology,41(9):887-892.

Document type: Journal Article
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IRMA ID 10491xPUB93
Title A bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation
Author Chang, Anne B.
Faoagali, J.
Cox, N.
Marchant, J.
Dean, B.
Petsky, H.
Masters, Ian B.
Journal Name Pediatric Pulmonology
Publication Date 2006
Volume Number 41
Issue Number 9
ISSN 1099-0496   (check CDU catalogue  open catalogue search in new window)
Start Page 887
End Page 892
Total Pages 6
Place of Publication Hoboken, US
Publisher John Wiley & Sons
Field of Research 1114 - Paediatrics and Reproductive Medicine
HERDC Category C1 - Journal Article (DEST)
Abstract There is currently no validated scoring system for quantification of airway secretions in children. A user friendly, valid scoring system of airway secretions during flexible bronchoscopy (FB) would be useful for comparative purposes in clinical medicine and research. The objective of this study was to validate our bronchoscopic secretion (BS) scoring system by examining the relationship between the amount of secretions seen at bronchoscopy with airway cellularity and microbiology. In 106 children undergoing FB, the relationship of BS grades with bronchocalveolar lavage (BAL) cellularity and infective state (bacterial and viral infections) were examined using receptor operator curves (ROC). BAL was obtained according to European Respiratory Society guidelines; first lavage for microbiology and second lavage for cellularity. Area under the ROC was significant for total cell count (TCC) and neutrophil % but not for lymphocyte %. BS grade significantly related to infection positive state (chi(trend) (2) = 5.85, P = 0.016). The area under the ROC for infection positive state versus BS grade was 0.645, 95% CI 0.527-0.763. The BS scoring system is a valid method for quantifying airway secretions in children undergoing bronchoscopy. The system related well to airway cellularity and neutrophilia, as well as to an airway infective state. However, the system is only complementary to cell counts and cultures and cannot replace these laboratory quantification techniques.
Keywords airway
cellularity
microbiological
DOI http://dx.doi.org/10.1002/ppul.20478   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 3652 (Journal) DA - 20060828IS - 8755-6863 (Print)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tPT - Validation StudiesSB - IM
 
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Created: Mon, 17 Dec 2007, 09:02:11 CST