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Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade

du Bois, Teresa Marie, Hsu, Ching-Wen, Li, Yulin, Tan, Yean Yeow, Deng, Chao and Huang, Xu-Feng (2008). Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical Research,33(7):1224-1231.

Document type: Journal Article

IRMA ID 75039815xPUB25
Title Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade
Author du Bois, Teresa Marie
Hsu, Ching-Wen
Li, Yulin
Tan, Yean Yeow
Deng, Chao
Huang, Xu-Feng
Journal Name Neurochemical Research
Publication Date 2008
Volume Number 33
Issue Number 7
eISSN 1573-6903
Start Page 1224
End Page 1231
Total Pages 8
Place of Publication United States of America
Publisher Springer New York LLC
Language English
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
Abstract This study examined how perinatal phencyclidine (PCP) treatment would affect dopamine D2 receptor and dopamine transporter (DAT) binding at different stages after treatment cessation. Female rat pups received injections of PCP (10 mg/kg, s.c.) or saline on postnatal day (PN)7, 9 and 11. D2 receptor and transporter binding was examined at four time-points (PN12, 18, 32 and 96) following injections. PCP treatment altered D2 receptor binding throughout development, with a final end-point of 22–33% decreased binding at adulthood in the nucleus accumbens and caudate putamen (P < 0.01), accompanied by a small but significant increase in DAT binding in the caudate putamen. Tyrosine hydroxylase mRNA expression was also significantly increased by 25% (P < 0.05) in the ventral tegmental area of adult rats, suggesting that this model may produce a long-term increase in dopamine output. This study demonstrates that early insult to the brain from NMDA receptor hypofunction alters the dopaminergic system at different stages of development.
DOI http://dx.doi.org/10.1007/s11064-007-9571-y   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://link.springer.com/article/10.1007/s11064-007-9571-y
 
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Created: Mon, 08 Dec 2014, 14:14:55 CST by Yean Tan