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Effect of chronic treatment with clozapine and haloperidol on 5-HT(2A and 2C) receptor mRNA expression in the rat brain.

Huang, Xu-Feng, Tan, Yean Yeow, Huang, Xin and Wang, Qing (2007). Effect of chronic treatment with clozapine and haloperidol on 5-HT(2A and 2C) receptor mRNA expression in the rat brain.. Neuroscience Research,59(3):314-321.

Document type: Journal Article
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Title Effect of chronic treatment with clozapine and haloperidol on 5-HT(2A and 2C) receptor mRNA expression in the rat brain.
Author Huang, Xu-Feng
Tan, Yean Yeow
Huang, Xin
Wang, Qing
Journal Name Neuroscience Research
Publication Date 2007
Volume Number 59
Issue Number 3
eISSN 1872-8111
Start Page 314
End Page 321
Total Pages 8
Place of Publication Ireland
Publisher Elsevier Ireland Ltd.
Language English
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
Abstract This study examined regional changes of 5-HT2A and 2Creceptor mRNA expression in the rat brain after chronic administration of clozapine (1.5 mg/kg/day) and haloperidol (2.0 mg/kg/day) for 36 days. 5-HT2A and 2C receptor mRNA expression and distributions were detected by in situhybridization after rats were sacrificed either 2 or 48 h after the last drug administration to examine both immediate and delayed effects following drug withdrawal. Following 2 h of drug withdrawal, it showed that clozapine administration significantly decreased 5-HT2Areceptor mRNA, predominantly in the nucleus accumbens (65%), hippocampus (80%), lasteral septal nucleus (61%) and striatum (68%) compared to controls, whilst rebound increases were observed in most of these regions 48 h later. In contrast, no change in 5-HT2Areceptor mRNA expression was found in the haloperidol treated groups either 2 h or 48 h after drug withdrawal. Clozapine also decreased 5-HT2Creceptor mRNA expression in the posteromedial cortical amygdala (32%) and substantia nigra (35%) 2 h after the last drug administration, while rebound effects were also observed 48 h later. 5-HT2Creceptor mRNA was only decreased in the substantia nigra at both 2 h (42%) and 48 h (54%) after the last haloperidol administration. Alterations in serotonin receptor expression in limbic system region such as the nucleus accumbens, hippocampus and lateral septal nucleus as well as the striatum may represent the specific regional targets that mediate the clinical effects of antipsychotics via the serotonin system.
Keywords Antipsychotics
Serotonin receptors
Clozapine
Haloperidol
Schizophrenia
Gene expression
DOI http://dx.doi.org/10.1016/j.neures.2007.08.001   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://www.sciencedirect.com/science/article/pii/S0168010207017233
 
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Created: Mon, 08 Dec 2014, 14:18:45 CST by Yean Tan