Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice.

Rahardjo, Gita L., Huang, Xu-Feng, Tan, Yean Yeow and Deng, Chao (2007). Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice.. Endocrinology,148(10):4704-4710.

Document type: Journal Article
Citation counts:
Google Scholar Search Google Scholar
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Tan_42495.pdf Published version application/pdf 178.34KB 40
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

Title Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice.
Author Rahardjo, Gita L.
Huang, Xu-Feng
Tan, Yean Yeow
Deng, Chao
Journal Name Endocrinology
Publication Date 2007
Volume Number 148
Issue Number 10
eISSN 1945-7170
Start Page 4704
End Page 4710
Total Pages 7
Place of Publication United States of America
Publisher The Endocrine Society
Language English
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
Abstract It is well known that the peripheral peptide YY (PYY)-central neuropeptide Y (NPY) Y2 receptor axis plays an important role in promoting negative energy balance regulation. Both the hypothalamus and medulla oblongata express a high level of Y2 receptors; however, the functional role of this receptor in chronic high-fat diet-induced obesity has not been fully examined. Using quantitative autoradiography, this study measured binding densities of total [125I]PYY and Y2 receptors in the hypothalamus and medulla of chronic high-fat diet-induced obese (DIO), obese-resistant, and low-fat-fed mice. Plasma PYY was also measured using RIA after 22 wk of dietary intervention. The results revealed that body weight gain was significantly higher in the obese mice, compared with the lean mice. Furthermore, PYY and NPY Y2 receptor binding densities in the medulla of the obese mice were significantly higher, compared with the lean mice, whereas the level of plasma PYY was significantly lower in the DIO mice than the low-fat-fed mice. In conclusion, this study showed that the DIO mice had low plasma PYY, which may have caused a compensatory up-regulation of PYY and Y2 receptor densities in the medulla. A low-level response of PYY-medullary regulation to positive energy balance may have contributed to the development of high-fat diet-induced obesity in DIO mice; conversely, a normal response of this regulatory axis in the obese-resistant mice may have contributed to the maintenance of body weight while on a high-fat diet.
DOI http://dx.doi.org/10.1210/en.2007-0107   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by The Endocrine Society.


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 42 Abstract Views, 40 File Downloads  -  Detailed Statistics
Created: Mon, 08 Dec 2014, 14:22:00 CST by Yean Tan