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The influences of gender and region on responses to 5-HT in the rat small intestine.

Liu, H., Irving, H.R., Tan, Y.Y., Meng, L., Chetty, N. and Coupar, I.M. (2004). The influences of gender and region on responses to 5-HT in the rat small intestine. . Pharmacology,72(4):220-224.

Document type: Journal Article
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Title The influences of gender and region on responses to 5-HT in the rat small intestine.
Author Liu, H.
Irving, H.R.
Tan, Y.Y.
Meng, L.
Chetty, N.
Coupar, I.M.
Journal Name Pharmacology
Publication Date 2004
Volume Number 72
Issue Number 4
eISSN 1423-0313
Start Page 220
End Page 224
Total Pages 5
Place of Publication Switzerland
Publisher S. Karger AG
Language English
Abstract The aim of this study was to obtain more information regarding the ‘atypical’ 5-HT7 receptor of the rat jejunum. 5-HT7-induced contractions of the jejunum were elicited by 5-HT in the presence of ondansetron. Maximal responses were slightly larger in tissues from male compared to female rats of comparable age, with Emax values of 97.2 ± 3.3 and 84.25 ± 4.3% respectively compared to acetylcholine as an internal standard. However, the pEC50 valuesfor 5-HT were not significantly different. The mRNA expression levels of the 5-HT7 receptor were similar in whole jejunum and longitudinal muscle tissues taken from males and females. It was also shown that the maximal response of the jejunum from male rats was larger than the responses from mid intestine and ileum. However, in female tissues, the Emax of the mid intestine was significantly larger than the ileum, but not different from the jejunum. The results provide further insights into the ‘atypical’ 5-HT7 receptor of the rat jejunum and are also useful in optimising the preparation for further studies.


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DOI http://dx.doi.org/10.1159/000080376   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to pulisher's version
URL http://www.karger.com/Article/Abstract/80376
 
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Created: Mon, 08 Dec 2014, 14:40:02 CST by Yean Tan