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Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia

Delvecchio, A., Currie, Bart J., McArthur, J. D., Walker, M. J. and Sriprakash, Kadaba S. (2002). Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia. Epidemiology and infection,128(3):391-396.

Document type: Journal Article
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Title Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia
Author Delvecchio, A.
Currie, Bart J.
McArthur, J. D.
Walker, M. J.
Sriprakash, Kadaba S.
Journal Name Epidemiology and infection
Publication Date 2002
Volume Number 128
Issue Number 3
ISSN 0950-2688   (check CDU catalogue open catalogue search in new window)
Start Page 391
End Page 396
Total Pages 6
Place of Publication Cambrdige, U.K
Publisher Cambridge University Press
Language English
Field of Research 320000 Medical and Health Sciences
Abstract Streptococcus pyogenes (group A streptococcus) strains may express several distinct fibronectin-binding proteins (FBPs) which are considered as major streptococcal adhesins. Of the FBPs, Sfbl was shown in vito to promote internalization of the bacterium into host cells and has been implicated in persistence. In the tropical Northern Territory, where group A streptococcal infection is common, multiple genotypes of the organism were found among isolates from invasive disease cases and no dominant strains were observed. To determine whether any FBPs is associated with invasive disease propensity of S. pyogenes, we have screened streptococcal isolates from bacteraemic and necrotizing fasciitis patients and isolates from uncomplicated infections for genetic endowment of 4 FBPs. No difference was observed in the distribution of sfbII, fbp54 and sfbI between the blood isolates and isolates from uncomplicated infection. We conclude that the presence of sfbI does not appear to promote invasive diseases, despite its association with persistence. We also show a higher proportion of group A streptococcus strains isolated from invasive disease cases possess prtFII when compared to strains isolated from non-invasive disease cases. We suggest that S. pyogenes may recruit different FBPs for different purposes.
Keywords tropical Australia
invasive-disease
isolates
Streptococcus pyogenes
DOI http://dx.doi.org/10.1017/S0950268802006787   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 1621 (Journal)


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